Process Modelling and Optimisation of Biomolecular Separations for Advanced Pharmaceutical Manufacturing

生物制造在制药、生物燃料、农用化学品等行业的主要产品合成中起着关键作用。这些生产线的规模扩大和下游加工对此类产品的商业化制造至关重要。为这些产品的放大和下游加工中遇到的问题寻找整体解决方案需要考虑许多因素，例如成本、可持续性、环境后果，所有这些都需要研究和开发新技术和设备。与专注于原始生物现象相反，该研究将专注于将合成生物学的早期阶段转化为完全开发的工业过程，以竞争和可持续的方式制造有意义的产品。

Biomanufacturing plays a key role in the synthesis of major products in variousindustries e.g. pharmaceuticals, biofuels, agrochemicals etc. The scale up anddownstream processing of these production lines is vital to the commercialmanufacture of such products. Searching for holistic solutions to the problemsencountered in the scale up and downstream processing of these products requiresthe consideration of numerous factors e.g. cost, sustainability, environmentalconsequence, all of which require research and development of new technologies anddevices. As opposed to focussing on the raw biological phenomena, the researchproposed will focus upon transforming the early stages of synthetic biology into fullydeveloped industrial processes which manufacture meaningful products in acompetitive and sustainable manner.