Exploring the Interplay between Genetic and Environmental Risk Factors for Childhood Conduct Problems in Global Perspective

拟议的研究项目将从三个大型纵向队列研究中提取数据，以进一步探索品行障碍轨迹的病因学。将使用非参数轨迹估计来估计传导问题的轨迹。社会环境风险因素将采用多项逻辑回归进行识别，多基因风险评分分析将研究这些环境风险因素如何与品行障碍的遗传易感性相互作用。此外，拟议的博士学位将采取全球视角，确定儿童行为问题风险途径的区域和其他潜在人群的具体变化。我的博士项目提案将比以往任何关于品行障碍病因学的研究提供更多的力量，并将对残疾人和临床实践有用，因为它将有助于我们进一步了解儿童行为问题。通过分析行为问题的因果因素，并认识到个人经历的确切问题，本博士学位获得的数据将有助于优化和/或发展服务，并提出干预和预防儿童和青少年破坏性行为问题的潜在目标。

The proposed research project will extract data from three,large longitudinal cohort studies to further explore theaetiology of conduct disorder trajectories. Trajectories ofconduct problems will be estimated using nonparametrictrajectory estimation. Socio-environmental risk factors willbe identified using multinomial logistic regression.Polygenic risk score analyses will investigate how theseenvironmental risk factors interact with the genetic liabilityfor conduct disorder. Additionally, the proposed PhD willtake a global perspective in identifying regional and otherpotential population specific variations in risk pathways forconduct problems among children. My PhD project proposalwill provide more power than any previous study on theaetiology of conduct disorder and will be useful for youngpeople and in clinical practice, as it will help to further ourunderstanding of child conduct problems. By discoveringthe causal factors of conduct problems and recognizing theexact problems which individuals go through, the dataobtained in this PhD will help to optimise and/or developservices and suggest potential targets for interventions andprevention of disruptive behavioural problems in childhoodand adolescence.