Bipolar Disorder Genetics: An Affected Sib Pair Family S

双相情感障碍（BP）是一种严重的遗传性疾病，影响约1%至2%的人口。遗传方式知之甚少，可能涉及多个中度影响的基因座。NIMH-IRP是参与一项多中心研究的12个地点之一，该研究集中于受影响的兄弟姐妹对家庭，其总体目标是从BP家庭中收集适合于连锁和关联研究的大量访谈和细胞系样本。整个项目由NIMH校外计划（MH 59535）资助。研究设计使用受影响的兄弟姐妹及其家庭成员。DNA和访谈数据收集和共享在这个财团的研究BP情感障碍。细胞系和访谈数据最终将根据NIMH标准免费提供给科学界。 NIMH-IRP网站目前已经招募并确定了2000多名BP兄弟姐妹及其家庭成员。(the在联盟的所有12个全国性站点中排名第二）。今年发表了使用自1998年以来收集的250个BP家族的上半年新数据进行全基因组筛选分析的初步结果。两个染色体区域（一个在17 q上，一个在6 q上）的lod得分为3.63和3.61，符合全基因组显著性的模拟标准。 本方案的继续将允许扩大受影响同胞对及其家庭成员的样本。这将增加识别BP和相关神经精神疾病相关染色体区域和基因的可能性。

Bipolar (BP) affective disorder is a severe, heritable condition affecting about one to two percent of the population. The mode of inheritance is poorly understood and probably involves multiple loci of moderate effect. The NIMH-IRP is one of twelve sites participating in a multi-center study concentrating on affected sibling pair families with the overall aim of collecting a large sample of interviews and cell lines from BP families suitable for linkage and association studies. The overall project is funded by an NIMH Extramural Program (MH 59535) grant. The study design uses affected sibling pairs and their family members. DNA and interview data are collected and shared within this consortium of investigators studying BP affective disorder. Cell lines and interview data will eventually be made freely available to the scientific community according to NIMH criteria. The NIMH-IRP site has now enrolled and ascertained a total of over 2000 individuals consisting of BP sibling pairs and their families. (the second highest number among all of the twelve nationwide sites in the Consortium). The initial results from a whole genome screen analysis using the first half of the new data from 250 BP families collected since 1998 was published this year. Two chromosomal regions (one on 17q and one on 6q) had lod scores of 3.63 and 3.61 that met simulation criteria for genome-wide significance. Continuation of this protocol will allow expansion of a sample of affected sibling pairs and their family members. This should add to the likelihood of identifying chromosomal regions and genes relevant to BP and related neuropsychiatric disorders.