ULTRASOUND-INDUCED LUNG DAMAGE ASSESSMENT

描述(由申请者提供)：建议的研究计划是一个基础 对已知的超声诱导生物的科学(非临床)评估 效果，其目标是确定 诊断性超声波与这种生物效应有关。医学部 如果诊断超声被证明是一种重要的 通过向临床医生建议这种风险来给患者带来医疗风险，以及 建议临床医生如何监控风险程度。同样， 如果诊断超声被证明不是一种 通过将其作为临床应用来消除对患者的重大医疗风险 担忧。无论是哪种情况，都有明显的医学意义。数据 决定这一问题所需的信息目前不可用。当前状态 关于超声对实验动物的肺损伤支持 认为诊断超声设备对人类构成风险。 拟议的研究旨在通过一个 跨学科的调查小组，他们有相当大的实验性 超声致肺损伤、肺组织形态和肺损伤的经验 功能研究，此外还有大量的实验和 具有超声生物物理学及相关物理领域的理论经验。 实验(以动物为基础)和理论(机制发展) 研究计划有四个具体目标，即：(1)评估超声 最小可检测到的肺出血发生的水平作为以下因素的函数 物种和年龄；(2)评估生理分支和功能， (3)对损伤机理进行实验评价；(4)研制出一种新的损伤机制。 一种针对一类一般损坏机制的理论。实验性的 设计：研究超声引起的肺出血作为两者的作用 年龄和物种，以及实验变量的设计都是为了 提供一个数据库，可以用来向人类推断这些发现 众生相。理论研究为理解 基本机制，因此另一种方法可用于外推到 人类。

DESCRIPTION (Provided by Applicant): The proposed research program is a basic science (non-clinical) evaluation of a known ultrasound-induced biological effect, the goal of which is to determine the current and future role of diagnostic ultrasound relative to this biological effect. The medical profession benefits if it is shown that diagnostic ultrasound is a significant medical risk to the patient by advising clinicians about this risk, and suggesting how the clinician can monitor the degree of risk. Likewise, the medical profession benefits if it is shown that diagnostic ultrasound is not a significant medical risk to the patient by eliminating this as a clinical concern. In either case, there is clear medical significance. The data necessary to decide this issue are not currently available. The current status regarding ultrasound-induced lung damage in experimental animals supports the view that diagnostic ultrasound equipment poses a risk to human beings. The proposed studies have been designed to address directly these issues by an interdisciplinary group of investigators who have considerable experimental experience with ultrasound-induced lung damage, lung morphology and lung function research studies, and in addition considerable experimental and theoretical experience with ultrasound biophysics and related physics areas. The experimental (animal-based) and theoretical (mechanism-development) research program has four specific aims, viz., (1) to evaluate ultrasound levels at which minimum detectable lung hemorrhage occurs as a function of species and age; (2) to evaluate the physiological ramifications and function, (3) to evaluate the damage mechanism experimentally; and (4) to develop a theory that addresses one general class of damage mechanisms. The experimental design investigates ultrasound-induced lung hemorrhage as a function of both age and species, and the design of the experimental variables all aim at providing a database that can be used to extrapolate the findings to human beings. The theoretical studies provide a mathematical basis for understanding the basic mechanism so that another approach is available for extrapolating to humans.