LONGITUDINAL STUDY: ALCOHOLICS ANONYMOUS

申请者摘要：戒酒者互助会(AA)是历史最悠久、使用最广泛的酒精相关问题互助计划，但AA也是 人们最不了解的戒酒方法。这个K02 申请表描述了一项职业发展计划，以扩大应聘者的 有精神病理学、精神药理学和统计学方面的知识 扩大和启动计划性纵向研究的目的 戒酒协会。明确了四个职业目标，并概述了五个机制 来实现这些目标。一种机制是为老年人举办以AA为重点的会议 科学家(R13)，将职业和研究目标联系起来，并提供一个论坛来 在AA研究中设定优先事项。知识的增长有助于 发展对AA的更生态的理解，并从 从资深方法学家到独立科学家。一项队列纵向研究 (N=300)拟设(R01)，参加者从 以社区为基础的AA、门诊和住院设置。的总体目标 这项研究是为了获得关于人们如何搬进、穿过和 随着时间的推移，他们对戒酒会的参与如何预测饮酒和 其他药物使用。对现代精神病理学和非法药物使用的思考 代表着当代再生障碍性贫血相关研究的显著拓宽，一 这反映了目前AA成员特征的变化。进阶 模拟AA出席率和参与轨迹的统计技术 在两年的时间内被提出，分析将解释 特定AA相关物质感知效用的潜在缓和效应 信仰和实践。对AA效用的感知的测量是 预计将对AA从属关系和 脱离关系，基于与戒酒相关的做法的程度的定义 和信念被采纳(以及为什么)，而不是基于AA会议出席本身。 此外，AA核心文献中的特定假设，如 禁欲和戒酒之间的区别，以及如何实现戒酒， 将会受到考验。学习目标和职业发展活动是精心编排的 作为一名独立科学家开始职业生涯，并成为 再生障碍性贫血相关研究的新兴分支学科。

APPLICANT'S ABSTRACT: Alcoholics Anonymous (AA) is the oldest and most widely used mutual-help program for alcohol-related problems, yet AA is also one of the least understood approaches for recovery from alcoholism. This K02 application describes a career development plan to enlarge the candidate's knowledge in psychopathology, psychopharmacology, and statistics for the purposes of expanding on, and initiating , programmatic longitudinal research on AA. Four career objectives are specified, and five mechanisms are outlined to achieve these goals. One mechanism, an AA-focused conference for senior scientists (R13), bridges career and research objectives and offers a forum to set priorities in AA research. Knowledge gains are instrumental for developing a more ecological understanding of AA, and for transitioning from a senior methodologist to an independent scientist. A cohort longitudinal study of AA (N=300) is proposed (R01), with participants recruited from community-based AA, outpatient, and inpatient settings. The overall aim of the study is to gain new knowledge about how people move into, through, and out of AA over time, and how their participation in AA predicts drinking and other drug use. Consideration of current psychopathology and illicit drug use represents a significant broadening of contemporary AA-related research, one that mirrors current changes in AA membership characteristics. Advanced statistical techniques for modeling AA attendance and involvement trajectories over a two-year period are proposed, analyses that will account for potentially moderating effects of perceived utility of specific AA-related beliefs and practices. Measurement of perceptions of AA utility is anticipated to offer radically new definitions of AA affiliation and disaffiliation, definitions based upon the extent that AA-related practices and beliefs are adopted (and why) rather than on AA meeting attendance per se. In addition, specific hypotheses in the core AA literature, such as the distinction between abstinence and sobriety, and how sobriety is achieved, will be tested. Study aims and career development activities are orchestrated to launch a career as an independent scientist, and to serve as a nexus for the emergent subdiscipline of AA-related research.