Inhalant Use/Dependence: Incidence and Comorbidity

描述（由申请者提供）：本提案寻求对吸入剂使用和依赖性流行病学研究的支持，包括全国代表性家庭居民样本中的发生率、决定因素、合并症和药物滥用服务利用。拟议的研究侧重于辍学者、育龄妇女、少数民族群体和吸毒父母的子女中吸入剂使用/依赖的程度和规模。将对最近几波全国药物滥用家庭调查和科摩罗全国调查的公共使用数据文件进行分析。吸入性滥用被描述为最普遍但最不被承认的毒品问题之一，尤其是在青少年中。目前对吸入剂使用的了解主要是基于吸入剂使用的普遍性。“这项拟议的研究涉及以下具体目标：（1）审查吸入剂开始使用的发生率和决定因素，（2）确定青年、辍学者、育龄妇女、少数民族群体和吸毒者子女使用/依赖吸入剂的模式和决定因素，（3）确定从吸入剂使用到其他非法药物使用的发展顺序中的亚组差异（女性、少数民族群体和多次或早发性吸毒者），（4）探索吸入剂依赖的自然过程、吸入剂使用者的亚型和吸入剂依赖的症状特征，（5）探讨共患病与物质滥用服务利用。拟议的分析将提供与吸入剂开始使用有关的发病率趋势和特征的估计数。将审查特殊分组使用/依赖吸入剂的模式和程度，以便更好地满足他们对预防或药物滥用服务的需要。还将确定易受精神病理学影响的吸入剂使用者亚组和服务不足的使用者亚组。所产生的信息将对决策者预测吸入剂使用问题的潜在负担和规划服务提供至关重要。我们对吸入剂使用的自然过程的知识差距将在未来的研究中详细说明。

DESCRIPTION (provided by applicant): This proposal seeks support for research on the epidemiology of inhalant use and dependence, including incidence, determinants, comorbidity, and substance abuse service utilization in nationally representative samples of household residents. The proposed research focuses on the extent and magnitude of inhalant use/dependence among school dropouts, females of childbearing ages, ethnic minority groups, and children of drug-using parents. Analyses will be performed on public use data files from multiple waves of recent National Household Surveys on Drug Abuse and the National Comorbidity Survey. Inhalant abuse has been described as one of the most pervasive yet least recognized drug problems, particularly among adolescents. Current knowledge about inhalant use is based primarily on the prevalence of inhalant "use." This proposed study addresses the following specific aims (1) to examine the incidence and determinants of inhalant initiation, (2) to determine the pattern and determinants of inhalant use/dependence among youths, school dropouts, females of childbearing ages, ethnic minority groups, and children of drug users, (3) to identify subgroup variation in the developmental sequence of inhalant use to other illicit drug use (females, ethnic minority groups, and multiple or early-onset drug users), (4) to explore the natural course of inhalant dependence, subtypes of inhalant users, and symptom profiles of inhalant dependence, and (5) to examine comorbidity and substance abuse service utilization. The proposed analysis will provide estimates of incidence trends and the characteristics related to onset of inhalant use. The pattern and magnitude of inhalant use/dependence by special subgroups will be examined so that their needs for prevention or substance abuse services can be better served. Subgroups of inhalant users vulnerable for psychopathology and underserved users will also be identified. The information generated will be vital to policy makers in predicting the potential burden of inhalant use problems and planning service delivery. Gaps in our knowledge of the natural course of inhalant use will be specified for future research.