Passive PAH and Micro-Camera Personal Monitoring System

描述（由申请人提供）： 本研究的总体目标是开发一种新型的敏感被动式 扩散采样器及其与小型化个人便携式录像机的结合使用 个人照射测量和评估用照相机系统 致癌的有机物。该研究将：1。 确定不同采样条件下的采样率（不同空气 浓度、采样持续时间、温度、湿度和面速度）; 2.在与以下各项的并排比较中评估采样器的性能： 经过验证的主动采样方法; 3.评估受试者的能力， 成功地佩戴和管理电池和胶带的更换;以及4.评价 采样器和MPPVCS捕获以下信息的组合有效性： 自愿接触致癌有机物。新型被动采样器 由一个扩散管组成，扩散管由10个0.5厘米（或更长）的 多毛细管气相色谱（GC）柱（900 μ l的40微米内部 直径）。由于扩散面积（内圆柱表面）的高值 扩散路径长度（每列的半径），采样率 将比传统的徽章或管型高出约1000倍 扩散采样器扩散管类型的几何结构将允许恒定采样 在广泛的采样条件下的速率。此外， 毛细管柱允许分析物直接热解吸到 分析仪器，避免了样品被溶剂稀释， 将灵敏度提高100倍。采样器可以用于 反复进行，不进行任何再生过程。在曝光会议期间， 重量轻，不显眼，MPPVCS将连接到受试者，以获得 关于致癌有机物来源的接近度的真实的时间信息， 一个人在特定时期的活动。MPPVCS小于1 磅，适合个人穿着。MPPVCS的使用可以 减少了与让摄像师跟踪 个人，减少与受试者完成 调查问卷和时间/活动日记，并避免信息丢失， 受试者的完成失败和失去意识的活动和 环境总之，我们建议开发和验证一种敏感的， 直接测量个人暴露于 致癌有机物联合使用新的扩散采样器和MPPVCS将 捕获暴露水平和暴露位置，以及 可能的来源结合的方法将提高社区的准确性 或居民评估个人暴露于致癌物， 流行病学研究，并提供了改进的暴露特征 进行风险评估。

DESCRIPTION (provided by applicant): The overall objective of the research is to develop a new sensitive passive diffusion sampler and couple its use to a miniaturized personal portable video camera system (MPPVCS) for the measurement and assessment of personal exposure to carcinogenic organics in personal air. The proposed research, will: 1. determine the sampling rate under different sampling conditions (different air concentration, sampling duration, temperature, humidity, and face velocity); 2. evaluate the performance of the sampler in side-by-side comparisons with proven active sampling method; 3. evaluate the ability of subjects to successfully wear and manage battery and tape changes; and 4. evaluate the combined effectiveness of the sampler and MPPVCS to capture information about volunteer personal exposures to carcinogenic organics. The new passive sampler consists of a denuder, which is made from 10 0.5-cm (or longer) sections of a multi-capillary gas chromatography (GC) column (900 of 40-micrometer internal diameter). Due to the high value of diffusive area (inner cylindrical surface) to diffusive path length (the radius of the each column), the sampling rate will be about 1000 times higher than the traditional badge or tube-type diffusive samplers. The denuder-type geometry would allow constant sampling rates in a wide range of sampling conditions. Also, the stationary phase of the capillary column allows directly thermal desorption of analytes to an analytical instrument, which avoids dilution of the sample by solvent and increase the sensitivity by a factor of 100. The sampler can be used repeatedly without any regeneration process. During the exposure session, a lightweight, unobtrusive, MPPVCS will be attached to the subject to obtain real time information about proximity to sources of carcinogenic organics and the individual's activities at a given period of time. MPPVCS is less than 1 pound and can be comfortable for individuals to wear. The use of MPPVCS can reduce the costs and burden associated with having a videographer track the individual, reduce the burden associated with having subject completing questionnaires and time/activity diaries, and avoid information loss due to subjects' completion failure and loss of awareness of their activities and the environment. In summary, we propose to develop and validate a sensitive, simple, and cost-effective technique to directly measure personal exposure to carcinogenic organics. Joint use of the new diffusive sampler and MPPVCS would capture both the levels of exposure and the locations of exposure, and possible sources. The combined approach will improve the accuracy of community or residential assessments of personal exposure to carcinogens for prospective epidemiologieal studies, and provide the improved characterization of exposure for risk assessments.