Examining the Role of HIF-1a and Snail-2 in Radiosensitivity of Oropharyngeal Squamous Cell Carcinoma

人乳头瘤病毒（HPV）诱导的口咽鳞状细胞癌的预后明显好于烟草和/或酒精引起的。预后良好是由于对放疗和化疗的反应较好，但确切的机制仍不清楚。该项目将在分子水平上研究这些机制，并最终引导我们制定策略，以改善HPV和非HPV诱导的口咽癌对放射治疗的反应。

Human papillomavirus (HPV)-induced oropharyngeal squamous cell carcinoma has a significantly better prognosis than that caused by tobacco and/or alcohol. The favorable prognosis is due to a better response to treatment with radiation therapy and chemotherapy but the exact mechanisms are still not clear. This project will investigate these mechanisims at the molecular level and ultimately it will lead us to the development of strategies to improve the response of both HPV and non-HPV induced oropharyngeal cancer to radiation therapy.