Exercise intolerance and impaired glycaemic control in heart failure patients: Identifying microvascular dysfunction as a novel mechanism

运动不耐受和血糖控制不良是射血分数正常的心力衰竭患者生活质量和寿命降低的重要原因。然而，目前的治疗方法在很大程度上是无效的，这可能是我们对这种情况背后的机制缺乏了解的副作用。这项研究将建立微血管功能障碍，而不是心脏功能障碍，作为健康状况不佳的潜在机制，并将确定运动作为一种有效的治疗策略。

Exercise intolerance and poor glucose control greatly contribute to reduced quality of life and longevity in heart failure patients with preserved ejection fraction. However, current treatments are largely ineffective, a likely side effect of our poor understanding of the mechanisms behind this condition. This research will establish microvascular dysfunction, rather than heart dysfunction, as the underlying mechanism of poor health and will identify exercise as an effective treatment strategy.