Biotech & Materials Research to Reduce Caries Disparity

描述（由申请人提供）：这是对资助申请编号R13 DE 015798 -01的修订，用于科学研讨会，目的是：（1）对公共卫生方法及其在预防差异人群中的幼儿龋齿方面的局限性进行最先进的评估。重要的是在这个评估将区分工程和技术与基础科学的应用问题。(2)评估最近在预防龋齿方面的新兴研究，包括：特定物种细菌粘附预防，生物膜生态操作，蔗糖驱动的酸生产，基因工程抗生素生产原位，氟化物和其他抗菌剂释放涂层的规避。(3)促进最终用户、口腔微生物学家以及材料和生物工程专家之间的对话，以开发新的预防技术，并将这些技术转让给工业和实践。(4)解决如何更有效地利用现有的大量基础和应用龋齿科学来加速公共卫生界的解决方案的问题。(5)制定一个研究议程，帮助州、联邦和私人资助机构确定关键的研究需求;不仅是为了新的技术解决方案，而且是为了将这些新技术转移到工业和公共卫生实践的推广机制。举办讲习班的理由是，科学和技术还没有为公共卫生从业人员和私营提供系统提供足够的实用工具，以解决低收入家庭的儿童和成人以及众多少数民族和种族群体的龋齿菌斑问题。为期两天半的会议将于2005年冬季在西雅图举行，与会者来自基础和应用学术牙科研究、生物工程和生物技术、政府和工业。会议将由西北/阿拉斯加减少口腔健康差异中心、华盛顿大学UWeb生物工程中心和唾液诊断项目共同主办。

DESCRIPTION (provided by applicant): This is a revision of Grant application No. R13DE015798-01 for a scientific workshop with the aim to: (1) Produce a state-of-the-art assessment of the public health approaches and their limitations in preventing early childhood dental caries in disparity populations. Important in this assessment will be differentiating applied problems of engineering and technology versus fundamental science. (2) Assess recent emerging research in the prevention of dental caries including: specific species bacterial adhesion prevention, biofilm ecology manipulation, circumvention of sucrose driven acid production, genetically engineered antibiotic production in situ, and fluoride- and other antimicrobial-release coatings. (3) Promote a dialogue between end-users, oral microbiologists, and materials and bioengineering experts in order to develop novel prevention technologies and implement the transfer of such technologies to industry and practice. (4) Address the question of what can be done to more effectively use the large body of basic and applied caries science already available to speed solutions to the public health community. (5) Develop a research agenda that will help state, federal, and private funding agencies identify critical research needs; not only for novel technological solutions but also on outreach mechanisms to transfer such novel technologies to industry and public health practice. The rationale for the workshop is that science and technology have not produced sufficient practical tools for public health practitioners and the private delivery system to address the plaque of dental caries that exists for children and adults from families with low incomes and for numerous ethnic minority and racial groups. The 2 1/2 day conference is to be held Winter 2005 in Seattle and involve participants from basic and applied academic dental research, bioengineering and biotechnology, government, and industry. The conference will be co-sponsored by the Northwest/Alaska Center to Reduce Oral Health Disparities, the University of Washington UWeb Bioengineering Center, and the Salivary Diagnostics Project.