Molecular & Cellular Bioenergetics Gordon Conference

简介（由申请人提供）：“细胞和分子生物能量学”戈登会议将于2004年6月20日至25日在新罕布什尔州安多弗的普罗克特学院举行。本次会议的传统焦点一直是氧化磷酸化和电子传递的机制。虽然这些仍然是中心主题，但即将召开的会议也将更多地关注生物能量学的细胞和分子方面。这个会议传统上是展示膜蛋白高分辨率结构的论坛，其中许多结构都是在这个地方首次提出的。此外，除了介绍X射线结构外，会议还利用光谱学、生物物理学、分子和细胞技术介绍膜蛋白的机制信息。最近在本次会议上讨论的系统包括lac渗透酶，ABC转运体，呼吸复合物II， III和IV和ATP合成酶。此外，会议还扩展到细胞生物能量学和疾病，介绍了v - atp酶，以及生物能量复合物的机制和目标。在2004年的会议上，将介绍最近膜蛋白的高分辨率结构和用于分析电子和质子传递机制的方法，以及蛋白质环境控制用于电子传递的辅因子的氧化还原电位的方法。一个不断扩大的兴趣领域是线粒体在衰老过程中所起的作用，以及呼吸链的组装和功能如何导致衰老和疾病。2004年会议的几个会议将专门讨论这一主题，将结构、机械和细胞/分子方法结合起来，以理解细胞生物能量学。分子与细胞生物能量学会议的参与者包括该领域的领导者，来自学术界，政府，工业界，包括初级科学家，如研究生/博士后研究员。组织戈登会议是为了最大限度地提供讨论和介绍这一领域最新发现的机会。

DESCRIPTION (provided by applicant): The Gordon Conference on "Cellular and Molecular Bioenergetics" will be held June 20-25, 2004 at Proctor Academy in Andover, New Hampshire. The traditional focus of this meeting has been on the mechanisms of oxidative phosphorylation and electron transport. Although these continue to be central themes the forthcoming conference will also focus more on cellular and molecular aspects of bioenergetics. This meeting has traditionally been a forum for presentation of high resolution structures of membrane proteins and many of these structures have been first presented at this venue. In addition, to the presentation of X- ray structures the meeting also presents mechanistic information about membrane proteins using spectroscopic, biophysical, molecular, and cellular techniques. Recently discussed systems at this meeting include the lac permease, ABC transporters, respiratory complexes II, III and IV and ATP synthase. In addition the meeting has expanded into cellular bioenergetics and disease, with presentations on V-ATPases, and the mechanisms and targeting of bioenergetic complexes. In the 2004 meeting presentations will be made on recent high resolution structures of membrane proteins and methods used to analyze electron and proton transport mechanisms and ways the protein environment controls the redox potentials of cofactors used for electron transport. An expanding area of interest is the role mitochondria play in the aging process and how assembly and function of the respiratory chain contributes to aging and disease. Several sessions in the 2004 conference will be devoted to this theme to bring together structural, mechanistic, and cellular/molecular approaches to understanding cellular bioenergetics. The participants in the Molecular and Cellular Bioenergetics conference include the leaders in the field, drawn from academics, government, industry, including junior scientists, such as graduate students/postdoctoral fellows. The Gordon conference is organized to maximize opportunity for discussion and presentation of the latest findings in this area.