Cleveland Cell Biology Symposium: Regulation

描述（由申请人提供）：本提案旨在为2004年4月22日至23日在俄亥俄州克利夫兰举行的为期两天的会议获得部分支持。 该主题将集中在不同实验室参与的细胞核的细胞生物学方面。 例如，许多研究已经描述了特定转录因子的结构、共价修饰或定位，这些转录因子在癌症、发育或神经疾病的背景下是重要的。 这些因子的功能都依赖于持续的核质转运和细胞核的完整性。 会议的目标是把这些人沿着与其他人谁是参与理解细胞核组织的基本原理和核质运输的机制在更广泛的条款。 结果应该是知识的密集综合，这将刺激学生和既定的教师。

DESCRIPTION (provided by applicant): This proposal is to obtain partial support for a two-day meeting in Cleveland, Ohio which takes place April 22-23, 2004. The subject matter will focus on aspects of Cell Biology of the nucleus in which diverse laboratories have participated. For example, many studies have described structure, covalent modification or localization of specific transcription factors which are important in the context of cancer, development or neurological disease. The functions of these factors all depend on ongoing nucleocytoplasmic transport and the integrity of the nucleus. The goal of the meeting is to bring together such individuals along with others who are involved with understanding the fundamentals of the organization of the nucleus and the mechanisms of nucleocytoplasmic transport in broader terms. The results should be an intense synthesis of knowledge which will be stimulating for both students and established faculty.