Mechanistic dissection of interplay between membrane traffic and apoptosis by mutations in the endosomal sorting regulatory protein Vps45.

真核细胞必须协调大量的细胞过程才能正常工作。了解这是如何实现的对于生物科学的许多领域都是至关重要的。Vps45蛋白调节通过内体系统的膜交通，并在防止细胞进入程序性细胞死亡（凋亡）中发挥作用。该项目将结合酵母遗传学、细胞生物学和生物化学来了解这两个关键的细胞通路是如何相互关联的。

Eukaryotic cells have to coordinate a large number of cellular processes inorder to function properly. Understanding how this is achieved is critical formany areas of the biosciences. The protein Vps45 regulates membranetraffic through the endosomal system and also plays a role in preventing cellsfrom entering programmed cell death (apoptosis). This project will use acombination of yeast genetics, cell biology and biochemistry to understandhow these two critical cellular pathways are interrelated.