T Cell Development

描述(由申请人提供)： 分子细胞和生物生物学方面的重大新进展为 对干细胞发育成不同的成熟T淋巴细胞谱系和亚群的机制的洞察。本次“T细胞发展会议”的总体目的和目标大致分为两大类：第一类是提供有关T细胞发展的最新和令人兴奋的研究成果，包括：与从干细胞发育T细胞有关的因素；TCR位点VDJ重组的调节；发育中的CD4和CD8的调节；调节Th1/Th2发育的转录因子；以及影响NK T细胞的发育和选择的因素。第二个总体目标是深入了解T细胞发育中的关键问题，包括：抑制与效应CD4细胞和CD8细胞的发育关系；基因重组和基因表达异常与肿瘤和其他疾病的关系；以及对CD4、CD8和NK T细胞的发育和TCR表达形成共识。因此，这次会议的首要目标是产生新的方法来了解支配T细胞发育的分子因素，并澄清和进一步发展我们对失调的T细胞发育和疾病机制之间的关系的理解。这次会议将把致力于这些问题的不同方面的科学家聚集在一起，并将促进将他们各种实验方法的信息整合到对T细胞在健康和疾病中的发育的新的合成和分子解释中。虽然有许多优秀的小型会议涉及T细胞发展的各个方面(例如戈登会议、FASE B会议和其他会议)，但这些会议没有深入的焦点，更多的是强调更广泛的免疫学领域的最新进展。此外，参加此类会议的科学家人数通常有限(约100人)，其中大多数是公认的主要研究人员，初级教员、博士后和研究生的空间有限。另一方面，较大的会议(例如，年度AAI会议)对许多年轻和发展中的科学家来说是可以参加的，但缺乏重点，也不能促进典型的Keystone研讨会的科学互动程度。因此，拟议的关于T细胞发展的Keystone研讨会的优势在于，允许大量初级科学家和正在接受培训的科学家参加并互动，同时专注于一个单一的 统一T细胞发育的主题。

DESCRIPTION (provided by applicant): Major new advances in molecular cellular, and organismal biology have provided profound insights into the mechanisms that govern the development of stem cells into the distinct lineages and subsets of mature T lymphocytes. The overall aims and goals of this 'T cell Development meeting' fall into two general categories: The first is to provide up-to-date and exciting research findings on T cell development including: factors involved in directing development of T cells from stem cells; regulation of VDJ recombination at the TCR loci; regulation of CD4 and CD8 in development; elucidation of transcription factors that regulate Th1/Th2 development; and factors that influence development and selection of NK T cells. The second general goal is to gain insight into pivotal problems in T cell development, which include: the developmental relationship of suppression to effector CD4 cells and CD8 cells; the relationship of abnormalities in gene recombination and gene expression to neoplasia and other diseases; and formation of a consensus view on development and TCR expression of CD4, CD8 and NK T cells. Thus, the overarching goal of this meeting is to generate new approaches to understanding the molecular factors that govern T cell development and to clarify and further develop our understanding of the relationship between dysregulated T cell development and disease mechanisms. This meeting will draw together scientists working on diverse aspects of these problems and will facilitate integration of the information from their various experimental approaches into a new synthesis and molecular explanation of T cell development in health and disease. While there are many excellent, small meetings that touch upon aspects of T cell development (e.g. the Gordon Conference, FASEB Conferences and others), these meetings do not have the depth of focus and more often highlight recent advances in the broader field of immunology. In addition, such meetings generally are attended by a limited number of scientists (about 100) of which most are established principle investigators with limited room for junior faculty, post-docs and graduate students. On the other hand, larger meetings (e.g. the annual AAI meeting) are accessible to a large number younger and developing scientists but lack focus and do not promote the degree of scientific interaction available in a typical Keystone Symposium. Thus, the proposed Keystone Symposia on T cell development offers the advantage of allowing a large number of junior scientists and scientists in training to attend and interact, while being focused under a single unifying theme of T cell development.