Expanding the power of genetic analysis of complex traits in multiply phenotyped twin sibships

我们的目标是确定影响常见疾病的基因，包括黑色素瘤，哮喘和心血管疾病。我们测量青春期双胞胎的皮肤，头发和眼睛的颜色以及各种血液特征。我们已经发现了与痣数量、眼睛颜色、皮肤损伤和几种不同血细胞类型有关的新基因。对于这些疾病特征中的每一个，都有更多的基因有待发现，这些基因将为新的治疗方法提供信息。我们计划对600个新家庭（2000个个体）进行基因分型，以帮助实现这一目标。

Our aim is to identify genes influencing common diseases including melanoma, asthma and cardiovascular disease. We measure adolescent twins for moliness, skin, hair and eye colour and a variety of blood traits. We have already found new genes for mole count, eye colour, skin damage, and several different blood cell types. For each of these disease traits there are many more genes to be found and these will inform new treatments. We plan to genotype 600 new families (2000 individuals) to help achieve this.