Investigating hippocampal dysfunction in people at clinical high risk of psychosis with implications for novel drug discovery

本博士项目的目的是在精神病患者中研究：1.地西泮对海马CBF的影响（使用动脉自旋标记测量）。我们假设地西泮组海马灌注低于安慰剂组。2.地西泮对静息状态下海马和其他相关脑区之间功能连接的影响（使用静息状态功能MRI测量）。我们假设与安慰剂条件相比，地西泮条件下海马功能连接性将得到改善（方向性依赖于相互脑区）。3.地西泮对上述成像指标之间相互作用的影响。我们假设地西泮条件下海马灌注减少与海马功能连接改善（方向性依赖于相互脑区）相关。

The aims of this PhD project will be to investigate in individuals at CHR of psychosis:1.The effect of diazepam on hippocampal CBF (measured using arterial spin labelling). We hypothesise that hippocampal perfusion will be lower in the diazepam condition compared to the placebo condition.2.The effect of diazepam on functional connectivity at rest between the hippocampi and other relevant brain regions (measured using resting-state functional MRI). We hypothesise that hippocampal functional connectivity will be improved(directionality dependent on the reciprocal brain region) in the diazepam condition compared to the placebo condition.3.The effect of diazepam on the interaction between the above imaging measures. We hypothesise that reduced hippocampal perfusion in the diazepam condition will be associated with improved hippocampal functional connectivity (directionality dependent on the reciprocal brain region).