Investigation of fMRI in the Presence of Jaw Motion

描述(由申请人提供)：该项目广泛的、长期的目标是确定最佳的MRI脉冲序列以及数据分析技术，以允许在存在颌骨和舌头运动的情况下进行功能磁共振研究。几个与健康相关的研究课题将从这一知识中受益。其中一个可以直接应用的研究领域是与咀嚼过程中的颞下颌关节疼痛相关的神经学因素的研究。此外，对说话障碍患者的神经科学研究可以极大地受益于在核磁共振机器内进行受试者的功能磁共振实验。到目前为止，颌骨运动引起的静态磁场变化引起的几何和强度失真一直困扰着颌骨运动下的快速磁共振成像，组织/空气和组织/骨骼界面的动态调制会改变磁场的不均匀性。在纠正这些问题方面取得了初步进展。需要进一步的研究来改进所使用的脉冲序列和数据分析技术，并找到在存在颌骨和舌头运动的情况下进行功能磁共振研究的最佳解决方案。

DESCRIPTION (provided by applicant): The broad, long-term objective of this project is to determine the best MRI pulse sequence as well as data-analysis techniques to allow fMRI studies in the presence of jaw and tongue motion. Several health-related research topics will benefit from this knowledge. One area of research to which this can be directly applied is the study of the neurological factors related to temporomandibular joint (TMJ) pain during chewing. Moreover, neuroscience studies of patients with speaking disorders can greatly benefit from the ability to run fMRI experiments of subjects speaking inside an MRI machine. Heretofore, rapid MR imaging of the brain in the presence of jaw motion has been plagued by geometric and intensity distortions due to the alteration of the static magnetic field caused by motion.The magnetic field inhomogeneity changes because of dynamic modulation of tissue/air and tissue/bone interfaces. Initial progress has been made to correct these problems. Further research is needed to improve the pulse sequence and the data-analysis techniques used and to find an optimum solution for engaging in fMRI research in the presence of jaw and tongue motion.