Early life antecedents of adult chronic disease

描述（由申请人提供）：以前被认为只发生在成人的疾病越来越多地在年轻人中被诊断出来。许多成人慢性疾病的亚临床前兆，如心血管疾病和2型糖尿病，起源于儿童和青少年时期。在生命早期——童年、青春期和青年期——测量的慢性病风险因素反映了影响成年慢性病发展的潜在生物学机制。将调查与这些风险模式有关的因素，如身体构成、性成熟、身体活动和其他传统心血管疾病风险因素。因此，该研究的总体目的是确定晚期疾病结局的早期预测因素。这一目标将通过赖特州立大学医学院终身健康研究中心的费尔斯纵向研究参与者的大量长期连续数据来解决。提出的研究目标将通过追求几个具体的研究问题来完成。这些问题的重点是确定在儿童和青少年时期测量的疾病风险因素在多大程度上可以预测个人的成年结果。要考虑的危险因素包括身体组成、胰岛素抵抗、性成熟、血压、血脂、身体活动、健康史和生活方式因素。该项目的完成将为早期发现有心血管疾病和2型糖尿病风险的人的亚临床疾病提供重要的新信息。

DESCRIPTION (provided by applicant): Diseases previously considered to occur exclusively in adults are increasingly diagnosed in younger adults. Many of the subclinical antecedents of adult chronic diseases such as cardiovascular disease and type 2 diabetes originate in childhood and adolescence. Chronic disease risk factors measured in early life--childhood, adolescence, and young adulthood--reflect the underlying biological mechanisms that influence the development of adult chronic disease. Factors associated with these risk patterns, such as aspects of body composition, sexual maturation, physical activity and other traditional cardiovascular disease risk factors, will be investigated. Thus, the general aim of the study is to identify early predictors of later disease outcomes. This aim will be addressed using the extensive long term serial data from the participants in the Fels Longitudinal Study based at the Lifespan Health Research Center, Wright State University School of Medicine. The proposed study objectives will be accomplished by pursuing several specific research questions. These questions focus on determining the extent to which disease risk factors measured in childhood and adolescence are predictive in individuals of adult outcomes. Risk factors to be considered include body composition, insulin resistance, sexual maturation, blood pressure, lipid profiles, physical activity, health history, and lifestyle factors. Completion of this project will yield important new information regarding early detection of subclinical disease in those at risk for cardiovascular disease and type 2 diabetes.