Core--Sheep Facility

绵羊核心的目标是提供一种机制，使该计划项目赠款的所有项目共享普通人员的服务，使具有成本效益的育种和动物维护计划能够达到极高的标准。这个核心的基本原理很简单。与单独满足每个研究项目的需求相比，由合格的个人组成的工作人员可以更有效、更经济地满足多个研究项目的需求。这一点尤其重要，因为这个核心的主要功能将是产生已经通过暴露于性腺类固醇在产前被编程的绵羊 已知的怀孕阶段。这需要在这种实验物种中管理生育、繁殖和早期产后护理方面的广泛经验和专业知识。绵羊核心的具体目标如下。具体目标1.实施一项育种计划，以培育在特定胎龄进行性腺类固醇产前治疗的绵羊和经车辆处理的对照绵羊，供组成本计划项目赠款的三个研究项目使用。具体目标2.通过三个相互关联的研究项目，协调绵羊的有效和经济利用。具体目标3.提供统一和高标准的动物养护和兽医护理。具体目标4.为生殖健康提供技术知识库 在绵羊身上进行研究。通过实现这些目标，绵羊核心将极大地提高计划项目赠款中所有项目的生产率。

The objective of the Sheep Core is to provide a mechanism whereby the services of common personnel are shared by all projects of this Program Project Grant, enabling cost-effective breeding and animal maintenance programs of exceptionally high standards. The underlying rationale for this Core is simple. A staff of well-qualified individuals can meet the needs of multiple research projects more effectively and economically than if each project were to meet its needs separately. This is especially important given that a major function of this core will be to generate sheep that have been programmed prenatally by exposure to gonadal steroids at known stages of pregnancy. This requires extensive experience and expertise of managing fertility, breeding, and early postnatal care in this experimental species. The Specific Aims of the Sheep Core are as follows. Specific Aim 1. To operate a breeding program to generate sheep that are prenatally treated with gonadal steroids at specific fetal ages and vehicle-treated control sheep for use by the three research projects that make up this Program Project Grant. Specific Aim 2. To coordinate effective and economical usage of sheep by three interrelated research projects. Specific Aim 3. To provide a uniform and high standard of animal maintenance and veterinary care. Specific Aim 4. To provide a technical knowledge base for reproductive research in sheep. By achieving these aims, the Sheep Core will greatly enhance the productivity of all projects in the Program Project Grant.