Collaborative Urological Research in Spinal Cord Injury

描述（由申请人提供）：泌尿系统并发症是 最常见和最具破坏性的健康问题。然而这 重要领域尚未得到重大研究关注。尤其 缺乏的是泌尿科医生，康复物理学家和基础之间的合作， 科学家SCI泌尿外科合作研究计划（CURP-SCI） 匹兹堡大学成立于1998年， 在众多对SCI神经生理学感兴趣的实验室中， 细胞生物学、组织力学和先进疗法。的目标 CURP-SCI是促进合作，跨学科的研究计划， 目的是为脊髓损伤后泌尿系统功能障碍提供合理的治疗方法。那里 项目中有四个项目和三个核心：项目1。机制 SCI后逼尿肌反射亢进的发展（William de Groat，药理学）; 项目2. SCI中膀胱力学的改变（Michael Sacks， 生物力学）;项目3。脊髓损伤患者膀胱癌的生物标志物 （Robert Getzenberg，泌尿科和匹兹堡癌症研究所）;和项目4。 神经性膀胱的新干预策略（Michael Chancellor， 泌尿科）。核心是：A。行政核心（Michael Chancellor）; B. 患者和组织库核心（Rajiv Dhir）;和C. SCI动物核心（William de Groat）。虽然这四个项目都将有动物研究，但也有 重点关注SCI患者的临床相关性和改善护理。 项目4（Chancellor博士）将在膀胱内香草素的研究中建立桥梁， 膀胱灌注树脂毒素的动物模型及同期临床试验 (RTX)神经源性膀胱患者。项目2和3也将直接 与人膀胱组织和尿液分析的临床相关性（核心B）。 该计划与区域SCI和MS计划相结合， 超过250万人。约翰·霍顿博士，康复科 医学，是SCI临床项目的主任。黛安·博雷洛-法兰西， 哲学博士、物理治疗和康复医学系，将 监督和指导临床结果和数据分析。该计划建立在 参与者对SCI研究的承诺以及 实验室的合作历史。它利用了 大学的大量资源，并将在更多的 超过25，000平方英尺的设备齐全的实验室和临床空间。这个程序 对于患者护理的进步和对 SCI和神经源性膀胱功能障碍。

DESCRIPTION (provided by applicant): Urological complications are one of the most common and devastating health problems for SCI patients. Yet this important field has not received significant research attention. Especially lacking is collaboration among urologists, rehabilitation physicists and basic scientists. The Collaborative Urologic Research Program in SCI (CURP-SCI) at the University of Pittsburgh was organized in 1998 to build upon the strengths of the large number of laboratories interested in SCI neurophysiology, cellular biology, tissue mechanics and advanced therapeutics. The goal of the CURP-SCI is to foster collaborative, interdisciplinary research programs with the aim of developing a rational therapy for SCI urologic dysfunction. There are four Projects and three Cores in the Program: Project 1. Mechanisms of detrusor hyperreflexia development after SCI (William de Groat, Pharmacology); Project 2. Alterations in bladder mechanics in SCI (Michael Sacks, Biomechanics); Project 3. Biomarkers of bladder cancer in SCI individuals (Robert Getzenberg, Urology and Pittsburgh Cancer Institute); and Project 4. Novel intervention strategies for neurogenic bladder (Michael Chancellor, Urology). The Cores are: A. Administrative Core (Michael Chancellor); B. Patient and Tissue Banking Core (Rajiv Dhir); and C. SCI Animal Core (William de Groat). Although all four projects will have animal studies, there is also focus on clinical correlation and improvement of care for SCI patients. Project 4 (Dr. Chancellor) will bridge a study of intravesical vanilloids in animal models and concurrent clinical trial of intravesical resiniferatoxin (RTX) in neurogenic bladder patients. Projects 2 and 3 will also have direct clinical correlation with analysis of human bladder tissue and urine (Core B). The program is integrated with the regional SCI and MS programs that serve over 2.5 million people. Dr. John Horton, Department of Rehabilitation Medicine, is the Director of the SCI Clinical Program. Diane Borello-France, Ph.D., Department of Physical Therapy and Rehabilitation Medicine, will oversee and direct clinical outcome and data analysis. This Program builds on the commitment of the participants to SCI research and the synergistic and collaborative history of the laboratories. It takes advantage of the considerable resources of the university and will be carried out in the more than 25,000 s.f. of fully equipped laboratory and clinical space. This Program is important for the advancement of patient care and basic understanding of SCI and neurogenic bladder dysfunction.