Interdisciplin Training-Genetics & Complex Disease(RMI)

描述（由申请人提供）： 我们的培训补助金提案“遗传学和复杂疾病的跨学科培训”直接满足了以综合方法开发博士前和博士后培训的需求，以应对当今公共卫生科学的挑战。我们的目标是培养一批年轻科学家，他们可以参与分子生物学，流行病学和生物统计学的交叉领域，成为综合和团队方法的领导者，以了解公共卫生竞技场中的遗传学和复杂疾病。在后基因组时代，我们开始理解和汇编人类群体中遗传变异的广度。精细使用这些信息需要开发先进的生物统计分析方法。此外，现代流行病学研究已经发展出一种增强的健康风险暴露观点，包括饮食、生活方式、代谢改变、社会经济地位沿着环境暴露等因素（例如，污染物、毒物）。后一种扩展的观点提供了更有意义和更精确的研究环境对复杂疾病的贡献。最后，为了在作为公共卫生标志的疾病预防方面取得重大进展，迫切需要将遗传进步转化为专注于预防常见和昂贵慢性病的计划和政策。只有了解基因图谱的重要性，我们才能确定谁将真正受益于公共干预。如果我们要真正了解与多种环境因素相互作用的常见遗传修饰剂的性质，就需要一种新的科学和新的科学工具箱。我们寻求建立一个跨学科教育的新轨道，将分子生物学，流行病学和生物统计学的边界与细胞生理学和代谢的核心基础交叉，这将发展重点关注复杂疾病中依赖于上下文的基因-环境相互作用的关键概念。我们对受训者的具体关注是尽可能广泛意义上的基因-环境相互作用，以及一组广义的复杂疾病，而不是个体综合征，认识到今天的科学在跨学科交叉的几个“核心”领域中基本上是确定的。我们将开发综合课程，赞助研讨会，建立一个新的研讨会系列，并培养互动的“核心”，使我们的学员能够承担未来的挑战，以确定疾病模式的分子特征。

DESCRIPTION (provided by applicant): Our training grant proposal "Interdisciplinary Training in Genetics and Complex Diseases" directly meets the need to develop pre- and post-doctoral training in an integrative approach to meet the challenges of today s public health science. Our goal is to develop a cadre of young scientists who can participate at the intersection of molecular biology, epidemiology, and biostatistics to become leaders in integrative and team approaches to understanding genetics and complex diseases in the public health arena. In the post-genomic era we are beginning to comprehend and compile the breadth of genetic variation within the human population. Refined use of this information requires the development of advanced methods of biostatistical analyses. In addition, modern epidemiological studies have evolved an enhanced view of health risk exposures to include factors such as diet, lifestyle, metabolic alterations, socioeconomic status along with environmental exposures (e.g., pollutants, toxicants). The latter expanded view provides more meaningful and precise studies of environmental contributions to complex disease. Finally, to make significant progress in disease prevention, a hallmark of public health, there is a pressing need to translate genetic advances into programs and policies focused on preventing common and costly chronic diseases. Only by understanding the importance of genetic profile can we identify who will truly benefit from public interventions. A new science and new scientific toolbox will be needed if we are to truly understand the nature of common genetic modifiers that interact with multiple environmental factors. We seek to establish a new track for interdisciplinary education that intersects the boundaries of molecular biology, epidemiology and biostatistics with a core foundation in cell physiology and metabolism that will develop key concepts focused on context-dependent gene-environment interactions in complex diseases. Our specific focus for trainees is on gene-environment interactions in the broadest possible sense, and on a generalized set of complex diseases rather than on an individual syndrome, with the recognition that science today is becoming substantially predicated in several "core" areas that intersect across disciplines. We will develop integrated coursework, sponsor workshops, establish a new seminar series, and foster interactive "cores" to enable our trainees to undertake the challenges that lie ahead to define the molecular signatures of disease patterns.