Exploring Scanning Ultrasound (SUS), a novel method to treat and prevent neurodegenerative disease

我们开发了一种新的扫描超声（SUS）协议，清除有毒的蛋白质聚集体和恢复记忆功能的阿尔茨海默病（AD）的小鼠模型，而不需要治疗药物。在这里，我们的目标是确定SUS是否具有预防潜力、是否存在协同作用，以及治疗性抗体与SUS结合是否会增强治疗效果。这将共同指导AD患者超声治疗的发展。

We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.