Carbonyl Alkylative Amination as a Tool for the Array Synthesis of Complex Amines

第一年：为CDT所有一年级学生成员提供一般培训活动。第2-4年：微尺度阵列合成允许以最小的材料使用化学相互作用的系统询问。锌介导羰基烷基化胺化反应的多组分性质和通用性使其成为生成各种复杂胺库的理想选择。我们将开发一个平台，用于高通量的微尺度复杂胺阵列的生成。微尺度反应条件和产物生成已得到证实，但反应物质的问题阻碍了简单的LCMS分析。相反，平行清除树脂为基础的净化允许通过核磁共振分析反应结果。提出了一种基于即时反应纯化和高通量核磁共振的新工作流程，并在微尺度上证实了CAA的反应性。然而，反应物质质量损失问题目前阻碍了进一步的优化和开发。

Year 1: Generic training activities for all first-year student members of the CDT.Year 2-4: Microscale array synthesis allows for the systematic interrogation of chemical interactions with minimal material use. The zinc-mediated carbonyl alkylative amination reaction's multicomponent nature and generality makes it ideal for generating diverse libraries of complex amines. We will develop a platform for the high throughput-enabled generation of microscale complex amine arrays. Microscale reaction conditions and product generation have been confirmed but issues with reactive species prevent simple LCMS analysis. Instead, parallel scavenger-resin based purification allows for reaction outcome analysis by NMR. A new workflow based on immediate reaction purification coupled with high throughput NMR is proposed, with the CAA reactivity on microscale confirmed. However, a reaction material mass loss issue currently prevents further optimisation and development.