Combining cutting edge molecular microbiology and super-resolution microscopy to reveal how bacteria divide, and how to stop them

在这个博士期间，我们将使用超分辨率显微镜来揭示隔膜是如何建立的，以及抗菌剂如何在物理上损害隔膜的完整性。这个与抗菌素耐药性密切相关的发现科学项目旨在揭示细菌分裂中关键的、潜在的可药物性薄弱环节。这项工作将在初级革兰氏阳性模式生物枯草芽孢杆菌中进行。由于细胞分裂蛋白的高度保守性，这里获得的见解与MRSA和肺炎链球菌等病原体直接相关。

During this PhD we will use super-resolution microscopy to reveal how the septum is built, and how antimicrobials physically compromise septum integrity. This strongly AMR-relevant discovery science project aims to reveal critical, potentially druggable, weak links in bacterial division. This work will be performed in the primary Gram-positive model organism Bacillus subtilis. Due to the highly conserved nature of cell division proteins, insight gained here is directly relevant to pathogens such as MRSA and Streptococcus pneumoniae.