Industrial Pollutants and Risk of Non-Hodgkins Lymphoma

描述（由申请人提供）：工业污染被怀疑是非霍奇金淋巴瘤（NHL）的原因，特别是因为这种癌症的发病率在20世纪下半叶急剧增加，稍微落后于美国工业生产扩大的时期。尽管有一个令人信服的假设，但很少有严格的研究探讨NHL和特定工业污染物之间的关联。随着桌面地理信息系统和工业地点和排放公共数据库的日益普及和易于使用，这类研究越来越容易进行。研究人员提出了一项长期暴露于工业污染物和NHL风险的病例对照研究。拟议研究的受试者是来自现有的NCI赞助的多中心研究的病例（n=855）和对照（n=781），从洛杉矶县和西雅图和底特律大都市区招募。将使用居住史来描述受试者在30年病因学关注期内的位置。将创建一个地理数据库用于暴露评估，以包含有关行业的信息，包括位置、操作类型和排放，这些信息记录在各种来源中，包括环境保护局的有毒物质释放清单（TRI）和来自加州、华盛顿和密歇根州的历史企业目录。我们将研究NHL风险与特定类型的行业，包括石油炼制和纸浆和造纸米尔斯厂。在根据排放量和气象数据绘制接触等值线之后，将审查与所关注的特定工业污染物（包括溶剂、多环芳烃和二恶英）有关的风险。该研究的长期居住史和潜在的混杂因素的现有数据的财富，除了使用GIS开发详细的暴露指标，将使研究人员作出有益的贡献，目前的知识状态有关的环境原因NHL。

DESCRIPTION (provided by applicant): Industrial pollution has been suspected as a cause of non-Hodgkin lymphoma (NHL) particularly because the rates of this cancer increased dramatically during the latter half of the 20th century, lagging slightly behind a period of expanded industrial production in the United States. Despite a compelling hypothesis, there have been few rigorous studies which examined the association between NHL and specific industrial pollutants. Such studies are becoming more readily implemented with the increasing availability and ease-of-use of desktop geographic information systems (GIS) and public databases of industry location and emissions. The investigators propose a case-control study of long-term environmental exposure to industrial pollutants and risk of NHL. Subjects for the proposed study are cases (n=855) and controls (n=781) from an existing NCI-sponsored multi-site study, recruited from Los Angeles County and the Seattle and Detroit metropolitan regions. Residential histories will be used to characterize the location of subjects during the 30-year time period of etiologic interest. A geodatabase will be created for exposure assessment purposes, to contain information on industries including location, operation type, and emissions, as recorded in various sources including the Environmental Protection Agency's Toxics Release Inventory (TRI) and historical business directories from California, Washington, and Michigan States. We will examine NHL risk in relation to specific types of industry, including petroleum refining and pulp and paper mills. The risk associated with specific industrial pollutants of interest, including solvents, polycyclic aromatic hydrocarbons, and dioxins, will be examined after developing exposure contours based on emissions quantities and meterologic data. The study's wealth of existing data on long-term residential history and potential confounders, in addition to the use of GIS for development of detailed exposure metrics, will enable the investigators to make a useful contribution to the current state of knowledge regarding environmental causes of NHL.