Non canonical cytokine signalling of haematopoietic growth factors in nociceptor

检测、反应和有效修复损伤或感染后的组织损伤的能力对生物体的长期生存至关重要。其中不可或缺的是炎症和疼痛之间的相互作用，这是通过对受伤或感染组织中伤害性通路的敏化来实现的。在行为上，这种保护性反应表现为痛觉过敏和超感痛觉，通过激活痛觉感觉神经元并使其对热、化学和机械刺激敏感。驻留或招募的血液来源的免疫细胞释放多种介质，这些细胞能够敏化疼痛通路，其中细胞因子起着关键作用。然而，在许多情况下，细胞因子引起疼痛和使伤害性感受器敏感的机制知之甚少。

The ability to detect, respond to and effectively repair tissue damage following injury or infection is critical to an organism's long-term survival. Integral to this is the interaction between inflammation and pain, through the sensitisation of nociceptive pathways in the injured or infected tissue. Behaviourally, this protective response manifests as hyperalgesia and allodynia through the activation and sensitisation of pain-sensing neurones to thermal, chemical and mechanical stimuli. Multiple mediators are released by resident or recruited blood-derived immune cells that are capable of sensitising pain pathways, and of these, cytokines play a critical role. However, in many cases, the mechanisms by which cytokines induce pain and sensitise nociceptors are poorly understood.