Protein Structure and Dynamics by Electron/Nuclear Paramagnetic Resonance

这个跨学科项目旨在建立新的磁共振方法来分析低浓度和生理条件下的蛋白质结构和运动，否则很难或不可能研究。它汇集了四个不同的研究小组，在先进的生物化学，现代磁谱学和高性能计算方面具有专业知识。该项目希望开发工具来研究蛋白质结构，蛋白质-蛋白质结合和蛋白质-配体相互作用的既定药物靶标。预期的结果包括快速告知药物如何工作的新技术，为许多研究生物分子的研究人员提供重大利益，并支持澳大利亚不断发展的生物技术部门。

This interdisciplinary project aims to establish new magnetic resonance methods for the analysis of protein structure and motion at low concentrations and in physiological conditions that are otherwise difficult or impossible to study. It brings together four different research groups with expertise in advanced biochemistry, modern magnetic spectroscopy and high-performance computing. The project expects to develop tools to study protein structure, protein-protein association and protein-ligand interactions of established drug-targets. Expected outcomes include new techniques that quickly inform how drugs work, providing significant benefits to many researchers studying biomolecules, and supporting Australia’s growing biotechnology sector.