Decarboxylative fluorination and trifluoromethylation of benzoic acids

目的：研究苯甲酸和杂芳羧酸转化为相应脱羧氟产品的新型催化方法。方法：学生将研究过渡金属催化剂的使用，以介导羧基C-C键的“活化”，从而导致脱羧过程。随后，该过程应与C-F键形成步骤相结合。新颖性：目前还没有广泛的方法来实现这种转变。苯甲酸非常容易获得，氟化基序在药物和其他生物活性分子中很常见。

Objective:This project will investigate the development of novel catalytic methods capable of transforming benzoic acids and heteroaromatic carboxylic acids into the corresponding decarboxofluorinated products. Approach:The student will examine the use of transition metal catalysts to mediate the 'activation' of the carboxyl C-C bond, resulting in a decarboxylative process. Subsequently, this process shall be coupled with a C-F bond forming step. Novelty:There are no broad methods available to carry out this transformation. Benzoic acids are extremely readily available, and fluorinated motifs are common in drugs and other biologically active molecules.