Human Perinatal Brain Injury and Outcome: MRI Assessemnt

描述（由申请方提供）：拟定研究结合了 候选人在儿科神经放射学和物理学以及当地的背景 擅长急性脑损伤的MR成像，脑结构的MR分析 和新生儿大脑生理学目标是建立候选人的专业知识 在最先进的神经成像技术和她的知识，新生儿 生理学，以便更好地研究MR可观测值和 新生儿脑损伤候选人处于完美的环境中， 从成人人群到新生儿人群使用的MR成像工具。 拟议的5年研究培训计划包括：1）新生儿 神经生理学，2）扩散、灌注、光谱学的理论和实践 和结构MR图像分析，以及3）临床研究设计、实验 统计和伦理。研究目标是开发MR技术， 预测急性期脑损伤的严重程度， 在2岁时评估结构性结果。我们假设， 在急性期确定的表观弥散（ADC）降低， 与不同的生理环境相关联，如由 灌注加权成像和质子波谱。我们还假设， 这些在生命最初几天观察到的生理变量预测了 2岁时原发性和继发性脑损伤的严重程度。的 项目预计只会帮助候选人建立一个独立的 研究生涯，并有助于了解围产期脑 损伤

DESCRIPTION (provided by applicant): The proposed study combines the candidate's background in pediatric neuroradiology and physics as well as local expertise in MR imaging of acute brain injury, MR analysis of brain structure and neonatal brain physiology. The goal is to build the candidate's expertise in stateoftheart neuroimaging techniques and her knowledge of neonatal physiology in order to better study the links between MR observables and neonatal brain injury. The candidate is in the perfect environment to extend the MR imaging tools used in the adult population to the neonatal population. The proposed 5year research training Program consists of 1) neonatal neurophysiology, 2) theories and practice of diffusion, perfusion, spectroscopy and structural MR image analysis, and 3) clinical research design, experimental statistics and ethics. The research goal is to develop MR techniques that predict the severity of brain injury in the acute period and to quantitatively assess the structural outcome at 2 years of age. We hypothesize that regions of decreased apparent diffusion (ADC) identified in the acute time period can be associated with different physiological environments, as determined by perfusion weighted imaging and proton spectroscopy. We also hypothesize that these observed physiological variables in the first days of life predict the severity of both the primary and secondary brain injury at 2 years of age. The project is expected to only help the candidate establish an independent research career and to contribute to an understanding of perinatal brain injury.