Expiratory muscle training in patients with Parkinson's

该项目测试了一种新的训练方法的结果，以加强呼吸系统的肌肉。以呼气肌为目标，该技术被称为呼气肌力量训练（埃姆斯特）。埃姆斯特为用户提供了一种实验性高压阈值装置，该装置在呼吸期间对肌肉施加高生理负荷。治疗持续4周，大部分培训在患者家中进行。我们打算测试埃姆斯特在一组特发性帕金森病（IPD）患者中的结果。帕金森氏病是一种使人衰弱的疾病，对运动功能（包括呼吸、咳嗽、吞咽和言语）具有公认的不良影响。本研究的总体目的是首先确定那些具有特定严重程度的IPD的患者是否可以改善呼气肌力量，其次确定哪些结果变量受到呼气肌力量改善的影响。我们预计治疗后呼吸、咳嗽、吞咽和言语的改善可归因于训练技术。对治疗组、假手术组和对照组中的30名Hoehn & Yahr、I-III期IPD受试者进行的三组研究将确定该技术的治疗效果。定量测量包括音量、流量、声压级和视频荧光指数的测量，以及听众感知测试，以确定该技术对整体音质和语音清晰度的影响。该项目的结果将提供有关埃姆斯特计划作为一种新技术的新信息。赠款的目标符合R21的使命。其潜在的影响是高，由于治疗方案的创新性和潜在的成本效益作为一种治疗方法。

This project tests the outcome of a novel training method for strengthening the muscles of the respiratory system. Targeting the expiratory muscles, the technique is referred to as expiratory muscle strength training (EMST). EMST provides the user with an experimental high-pressure threshold device which places a high physiological load on the muscles during breathing. The treatment lasts 4 weeks and the majority of the training takes place in the person's home. We intend to test the outcome of EMST in a group of individuals with idiopathic Parkinson disease (IPD). Parkinson's disease is a debilitating disease with well-recognized adverse effects on motor function including breathing, cough, swallow and speech. The general purpose of this research is to first determine if those with a specific severity of IPD can improve expiratory muscle strength and secondly to determine what outcome variables are affected by the improvements in expiratory muscle strength. We anticipate improvements in breathing, cough, swallow and speech following treatment that are attributable to the training technique. Study of three groups of 30 subjects with Hoehn & Yahr, stage I-III IPD in a treatment, sham and control group will define the therapeutic effect of this technique. Quantitative measures include measures of volume, flow, sound pressure level and videoflourographic indices as well as listener perception tests to determine the technique's impact on overall sound quality and speech intelligibility. Results from this project will provide new information about the EMST program as a novel technique. The goals of the grant meet the mission of the R21. Its potential impact is high due to the therapy program's innovative nature and potential cost-effectiveness as a treatment approach.