Psychiatric Disorders/HIV Interface in Women in Congo

描述(由申请人提供)：北卡罗来纳大学公共卫生学院(UNC)、约翰霍普金斯大学医学院(JHU)和比利时鲁汶天主教大学(CU)社会文化人类学系非洲研究中心建议加强刚果金沙萨金沙萨大学撒哈拉以南非洲社会科学教学研究中心(CERDAS)/金沙萨公共卫生学院(KSPH)的精神疾病(PD)研究能力。这一多步骤的研究和能力建设进程将通过扩大/加强现有的CEDAS/KSPH与北卡罗来纳大学、JHU和CU的伙伴关系来进行。我们最初的努力将侧重于：1)在金沙萨(人口约900万)最大的孕产妇金加萨尼产妇(KM)(每年分娩次数约10 000次)(人口约200万)的金沙萨，观察到在大量孕妇及其核心家庭中观察到的艾滋病毒感染事件和流行病例之间的相互作用。恩吉利也将是我们基于社区的(CB)PD研究的地点。2)同一KM人群中产后抑郁(PND)的发生率和后果。 我们的研究将是CB。帕金森氏症通常是污名化的。Cedras/CU已经在恩吉利进行了15年以上的实地研究，由传统治疗师照顾那些在与西方化设施不接触的“隐蔽”的当地治疗地点进行治疗的帕金森氏症患者。我们的团队与这些当地的治疗师有可靠的、可信的/有效的联系。将我们的研究设在KM/Ndjili将进一步促进我们进入目标社区的努力，以“挖掘”那些原本不被列举(在EPI研究中很重要)、未被诊断和未接受治疗的PD患者。我们打算利用我们在KM的高效预防母婴艾滋病毒传播干预计划的现有基础设施来研究我们人口中的PD和PND。 在R24拨款中，我们将首先确定短期研究的基本领域，并指派KSPH公共卫生硕士学者进行仔细指导的研究。精心挑选的大脑障碍研究员(BDF)将在鲁汶、巴尔的摩/教堂山接受12个月的指导培训。回到金沙萨，BDF将获得用于其他研究项目的再入赠款，以通知我们R01赠款的准备工作。所有合作者在金沙萨举行的定期会议将使我们能够集体准备一份竞争性的R01赠款。

DESCRIPTION (provided by applicant): University of North Carolina's School of Public Health (UNC), Johns Hopkins University's School of Medicine (JHU) and the African Studies Center, Department of Social and Cultural Anthropology, Catholic University (CU), Leuven, Belgium propose to strengthen the psychiatric disorders (PD) research capacity of the Center for Teaching and Research in Social Science for sub-Saharan Africa (CERDAS)/Kinshasa School of Public Health (KSPH), University of Kinshasa in Kinshasa, Congo. This multi-step research and capacity building process will occur through expansion/reinforcement of the existing CERDAS/KSPH partnership with UNC, JHU and CU. Our initial efforts will focus on: 1) The interplay between PD and incident and prevalent cases of HIV infection observed in large cohorts of pregnant women and their nuclear families we currently follow in Kinshasa's (population approximately 9 million) largest maternity, Kingasani Maternity (KM) (annual number of deliveries approximately 10,000) located in Ndjili (population approximately 2 million). Ndjili will also be the site for our community-based (CB) PD research. 2) The incidence and consequences of postnatal depression (PND) in this same KM population. Our studies will be CB. PD is often stigmatizing. CEDRAS/CU has conducted field research in Ndjili for 15+ years with traditional healers caring for patients with PD who sock treatment at "hidden" local healing sites operating out of contact with Western-orientated facilities. Our group has solid credible/effective contact with these local healers. Basing our studies at KM/Ndjili will further facilitate our efforts to reach into the target community to "unearth" patients with PD who would otherwise remain unenumerated (important in epi studies), undiagnosed and untreated. We intend to use the existing infrastructure at our highly effective prevention of mother to child HIV transmission intervention program at KM to study PD and PND in our population. In the R24 grant we will first identify essential areas for short-term research and assign KSPH MPH scholar physicians to conduct carefully mentored research. Carefully selected Brain Disorder Fellows (BDF) will receive 12 months mentored training in Leuven Baltimore/Chapel Hill. Returning to Kinshasa, BDF will receive re-entry grants for additional research projects to inform our R01 grant preparation. Periodic meetings in Kinshasa among all collaborators will enable us to collectively prepare a competitive R01 grant.