Genetic Models of Cardiovascular Renal & Pulmonary

描述（由申请人提供）： 我们建议建立一个多学科的研究培训计划，将整合犹他州大学领先的临床和基础研究科学家的专业知识，使用动物模型来研究心血管，肾脏和肺部疾病的遗传机制。我们将提供博士后培训（临床科学家或博士），研究生培训和短期培训，使用动物研究与疾病有关的基因和途径，主要目标是改善诊断和确定治疗常见心血管、肾脏和肺部疾病的新药靶点。不仅必须发展生产转基因动物的专门知识，而且还必须发展鉴定和分析其表型的专门知识。学员将接触到广泛的新兴技术领域的基因操作，定量遗传学，功能基因组学，生物化学，生理学，成像，行为，生物信息学和统计学需要进行全面的研究，在遗传学的常见疾病。来自临床和基础科学部门的36名教师将担任学员的导师，一方面来自心脏病学，内分泌学，血液学，肾脏病学，肺科，儿科学和医学遗传学的临床部门或部门，另一方面来自人类遗传学，生物化学，医学信息学，遗传流行病学，生物数学，计算机科学和数学。研究生和研究生两级培训方案的教学部分已经在大学实施。来自临床和基础科学部门的教师对个别学生的双重指导，以及在课程和研究计划中开发的观点的气息，应该为学员提供坚实的准备，以参与未来生物医学研究的多学科研究团队。 (END（见摘要）

DESCRIPTION (provided by applicant): We propose the creation of a multidisciplinary Research Training Program that will integrate the expertise of leading clinical and fundamental research scientists at the University of Utah in the use of animal models to investigate genetic mechanisms underlying cardiovascular, renal and pulmonary diseases. We will offer post-doctoral training (clinical-scientists or Ph.D.), graduate training, and short-term training in the use of animals to investigate genes and pathways involved in disease, with the primary goals of improving diagnosis and identifying new drug targets for treatment of common cardiovascular, renal, and pulmonary diseases. Expertise must be developed not only in generating genetically altered animals but also in characterizing and analyzing their phenotypes. Trainees will be exposed to the broad range of emerging technologies in the fields of gene manipulation, quantitative genetics, functional genomics, biochemistry, physiology, imaging, behavior, bioinformatics and statistics required to carry out comprehensive research in the genetics of common disease. Thirty six faculty members from clinical and basic sciences departments will serve as preceptors for the trainees, drawn on one hand from the Clinical Divisions or Departments of Cardiology, Endocrinology, Hematology, Nephrology, Pulmonary Division, Pediatrics, and Medical Genetics, and on the other hand from the Basic Sciences Departments or Divisions of Human Genetics, Biochemistry, Medical Informatics, Genetic Epidemiology, Biomathematics, Computer Science and Mathematics. The didactic part of the Training Program at both the Post-Graduate and Graduate levels are already in place at the University. Dual mentoring of individual students by faculty from clinical and basic sciences departments, together with the breath of perspective developed in the curriculum and the research program, should provide trainees with a solid preparation to participate in the multidisciplinary research teams of future biomedical research. (END OF ABSTRACT)