Training in Synaptic Neurobiology

描述（由申请人提供） 利用生物化学，分子生物学， 细胞生物学、解剖学和生理学是推进我们理解 突触的形成、组织和功能。建议的目的 该计划是提供博士后和博士前培训重点在突触 神经生物学我们的培训战略得益于其强调 需要采取跨学科办法的一系列具体的当前问题， 仍然保持广泛的培训经验和接触广泛的 各种智力工具。这项研究是基础， 了解--并有望减轻--许多神经系统疾病。的 培训将由分子，细胞和 整合神经科学（MCIN）计划。教师来自四个 两个学院的部门。这些教师，沿着与其他14人，有 组织并教授核心神经生物学课程， 文学、实验和讨论课程。在该方案中， 个人谁可以应用这些基本知识在实际治疗 神经系统疾病，通过他们作为临床科学家的联合任命 在科罗拉多州立大学兽医教学医院。2000 - 2001年， 15名博士前和20名博士后学生接受了培训 培训学院的实验室。这些学员得到了 个人研究赠款、博士后和研究生奖学金，以及 MCIN项目的研究生助学金。大部分的博士前实习生 拥有传统学科的学位， 参与部门或通过MCIN计划。所有的博士后 受训人员直接与导师联系，没有被聘用。 该计划中所描述的这一建议将允许我们招募4博士后 培训生和支持2名博士生参加 跨学科项目涉及多个实验室，最多3个 年这些新成员对于加强 实验室之间，并将为学员提供一个独特的机会， 获得在今天的研究成功所需的多学科技能 环境所有受训者都能接触到现代细胞和分子 生物设施，包括计算机增强光，共聚焦和电子 显微镜检查（中压），结合电生理学和 光学/荧光显微镜设备，大分子合成和 测序设施、基因克隆和细胞转染实验室，以及 高质量实验动物资源设施。

DESCRIPTION (provided by applicant) Integrated investigations using methods from biochemistry, molecular biology, cell biology, anatomy and physiology are central to advancing our understanding of synapse formation, organization and function. The purpose of the proposed program is to provide postdoctoral and predoctoral training focused in synaptic neurobiology. Our strategy for training gains from its ability to emphasize a specific set of current issues that require an interdisciplinary approach while still maintaining a breadth of training experience and exposure to a wide variety of intellectual tools. This research is the foundation for understanding - and hopefully alleviating - numerous neurological diseases. The training will be provided by 7 faculty members of the Molecular, Cellular and Integrative Neuroscience (MCIN) Program. The faculty members come from four departments in two colleges. These faculty, along with 14 others, have organized and teach a core neurobiology curriculum offering lecture, literature, laboratory and discussion courses. Within the program are individuals who can apply this fundamental knowledge in actual treatment of neurological disorders, through their joint appointments as clinical scientists at the Colorado State University Veterinary Teaching Hospital. In 2000 - 2001, 15 predoctoral and 20 postdoctoral students received training in the laboratories of the training faculty. These trainees were supported from individual research grants, postdoctoral and graduate fellowships, and by graduate assistantships from the MCIN Program. Most of the predoctoral trainees have degrees in traditional disciplines and were recruited either through participating departments or through the MCIN program. All of the postdoctoral trainees initiated contact with their mentors directly and were not recruited. The program described in this proposal would allow us to recruit 4 postdoctoral trainees and support 2 predoctoral students to participate in cross-disciplinary projects involving more than one laboratory for up to 3 years. These recruits will be important for strengthening the interactions between laboratories and will provide the trainees with a unique opportunity to acquire the multidisciplinary skills needed for success in today's research environment. All trainees will have access to modern cell and molecular biological facilities including computer enhanced light, confocal and electron microscopy (intermediate voltage), combined electrophysiology and light/fluorescence microscopy equipment, macromolecular synthesis and sequencing facilities, gene cloning and cell transfection laboratories, and a high quality lab animal resource facility.