Facility Airborne Biological Toxin Alarm System

该项目将开发一种实时现场传感器，以保护室内空气环境免受生物毒素的意外或故意释放。设施气载生物毒素警报系统（FABTAS）是马萨诸塞州总医院医学与创新技术集成中心（CIMIT）生物防御计划和马萨诸塞州大学达特茅斯（UMD）肉毒杆菌研究实验室的一个项目。在该项目中，场不对称离子迁移谱仪（FAIMS）检测器将与模式识别软件相结合，以立即识别隐藏在室内空气处理（HVAC）系统中的生物背景中的生物毒素特征。在 在这个为期12个月的项目结束后，CIMIT将生产一种易于集成、低成本、高灵敏度的探测器，用于对室内空气环境中存在的生物毒素发出警报。除了防止故意的生物毒素攻击外，该检测系统还将检测对室内皮革的更多常规威胁，如霉菌和真菌（曲霉菌）以及细菌（军团菌）。这些任务将通过首先生成模拟肉毒杆菌、蓖麻毒素、石房蛤毒素和ET-B的原型生物毒素的无害模拟物的离子特征曲线来完成。以下是非危险毒素代理的特征优化 该系统将在UMASS-Dartmouth的安全BL 3设施中使用批准的低浓度灭活生物毒素重复签名表征。在完成灭活毒素的特征描述后，该团队将FAIMS连接到微流体运输和商业“现成空气采样系统”上，该系统已成功用于其他基于FAIMS的化学HVAC保护项目，新原型将安装在CIMIT的测试HVAC系统中。在这一扩展的现场测试中，将在实际现场条件下评估FABTAS的假阳性警报率、可靠性、服务便利性和维护成本。在现场测试之后，FABTAS性能参数将 我们会进行检讨，并会对FABTAS作出所需的修订。 该项目通过产生新技术，方法和诊断特征库来实现CDC支持的研究目标，这些技术，方法和诊断特征库可用于改善室内空气环境中生物恐怖主义或自然发生的感染（或过敏）的即时检测，缓解和预防。

This project will develop a real-time, on-site sensor to protect indoor air environments against accidental or ntentional release of biological toxins. The Facility Airborne Biological Toxin Alarm System (FABTAS) is a esearch program of the Biodefense Program at the Center for Integration of Medicine and Innovative Technology (CIMIT) at Massachusetts General Hospital, and the Botulism Research Laboratory at University of Massachusetts Dartmouth (UMD). In this project, a Field Asymmetric Ion Mobility Spectrometer (FAIMS) detector will be coupled with pattern recognition software to allow for immediate recognition of biological toxin signatures hidden within the biological background present in indoor air handling (HVAC) systems. At the conclusion of this 12-month project, CIMIT will produce an easily integrated, low cost, high-sensitivity detector to alert against the presence of biological toxins in indoor air environments. In addition to protecting against intentional biological toxin attacks, the detection system will detect more routine threats to indoor lealth such as molds and fungi (Aspergillus) and bacteria (Legionella). These tasks will be accomplished by first generating ion signatures profiles of non-hazardous simulants that mimic the protypic biological toxins botulism, ricin, saxitoxin and ET-B. Following optimization of signatures for the non-hazarous toxin proxies the system will repeat signature characterization in UMASS-Dartmouth's secure BL3 facility using approved ow concentrations of inactivated biological toxins. Following completion of signature characterization of inactivated toxins the team will attach the FAIMS to a microfluidics transport and commercial "off the shelf air sampling system that that has been successfully used in other FAIMS based chemical HVAC protection projects and the new prototype will be installed in CIMIT's test HVAC system. During this extended field test the false positive alarm rates, reliability, ease of service and cost of maintanance of the FABTAS will be assessed under realistic field conditions. Following the field test, the FABTAS performance parameters will be reviewed and necessary modifications in the FABTAS will be implmented. This project meets the goals of CDC-supported research by generating new technologies, methodologies and diagnostic signature libraries which can be used to improve the immediate detection, mitigation and prevention of bioterrorism or naturally-occuring infection (or allergies) in indoor air environments.