Determination of radiation dose to bone tumours during Molecular Radiotherapy using patient specific phantom imaging and Monte Carlo modelling

本项目的目的是证明在临床分子放射治疗（MRT）过程中使用单光子发射计算机断层扫描（SPECT）建立骨肿瘤精确体内剂量测定的可行性。随着针对前列腺癌的定向MRT引入欧洲，并且现在扩展到英国，迫切需要开发用于这种疾病中占主导地位的骨转移的准确辐射剂量测定。该提案将扩展我们先前开发的基于蒙特卡罗（MC）模拟和逼真的3D打印患者器官的方法，进入骨肿瘤或转移瘤内递送的剂量的新的和复杂的区域。这将通过将对骨骼和肿瘤的结构和关系的详细了解结合到我们的MC模型中，并通过3D打印体模进行实验验证来实现。目前，在全球范围内，在确定剂量方面存在很大差异，无法提出统一的方法。我们提出的项目源于辐射与物质的核心核物理相互作用，并与战略医疗保健领域保持一致。CASE学生将在曼彻斯特大学核物理小组和克里斯蒂NHS基金会信托核医学部门之间建立的合作中工作，以解决这个问题。

The aim of this project is to demonstrate the feasibility of establishing accurate in-vivo dosimetry for bone tumours during clinical Molecular Radiotherapy (MRT) using Single Photon Emission Computed Tomography (SPECT). With the introduction of directed MRT for prostate cancer into Europe, and now spreading to the UK, there is an urgent need for development of accurate radiation dosimetry for the bone metastases that dominate in this disease. This proposal will extend our previously developed approach, based on Monte- Carlo (MC) simulations and realistic 3D printed patient organs, into the novel and complex area of dose delivered within a bone tumours or metastasis. This will be achieved by incorporating a detailed understanding of the structure and relationship of bone and tumour into our MC models with experimental validation from 3D printed phantoms. At present worldwide, there are large discrepancies in determining dose and a harmonised approach cannot be proposed. Our proposed project stems from core nuclear physics interactions of radiation with matter and aligns with the strategic healthcare area. The CASE student will work within our established collaboration between The University of Manchester nuclear physics group and The Christie NHS Foundation Trust nuclear medicine department to address this problem.