Pharmacology Training Grant

描述(由申请人提供)：申请资助27-31年一个非常成功的药理学博士学位课程，其目标是招募和培养化学、生物学和医学交叉领域的研究领导者。该计划促进了独立博士研究人员的发展，他们在治疗剂的设计和表征以及它们对生命系统的影响的研究方面具有专业知识。跨学科训练包括严格的教学和强化的研究训练。生物有机化学、结构生物学、生物化学、分子生物学、细胞生物学和生物信息学等核心课程为学生提供生物医学科学的基本概念。我们的研究生药理学课程教授药理学的定量基础和药物作用的机制。小组教程提供对特定兴趣领域的深入探索，选修课支持从分析化学到临床药理学等领域的重点培训。学生在进入该项目时就开始研究，在他们第一年选择论文研究顾问之前进行实验室研究轮换。在论文咨询委员会的指导下，学生在36个项目教员的实验室中进行重要研究，每个教员都指导着得到充分支持的强有力的研究项目。博士研究领域包括药物设计、蛋白质结构和功能、糖生物学和血脂功能、分子成像、病毒学、微生物学、免疫学、肿瘤学和神经药理学。学生作为演讲者参加药理学研究研讨会、期刊俱乐部和实验室会议，并被鼓励在国内和国际会议上展示他们的研究。完成论文研究后，学生们写一篇博士论文，并由论文咨询委员会进行批评，然后在公开研讨会上展示他们的博士研究成果。 该项目成立于1969年，自1978年以来由美国国立卫生研究院资助，已授予近150个博士学位。目前有39名学员参加了该项目，另有15名学员确认将于今年夏天入学。在过去5年中，入学人数平均为每年11人(7-15人)。学生通常在4-6年内获得博士学位。培训设施包括部门和机构的教室、研讨会、报告厅和图书馆，以及位于约翰·霍普金斯大学医学院、公共卫生学院和艺术与科学学院的36名教职员工设备齐全的实验室。高端分析仪器包括机器人高通量筛选、高端和无人值守质谱仪，以及800 MHz核磁共振，可用于学生研究。在过去的几十年里，该项目的学生为生物医学的发现做出了有意义的贡献，该项目的毕业生在世界各地的顶级学术、工业和政府机构担任研究、教学和领导职位。

DESCRIPTION (provided by applicant): Funding is requested for years 27-31 of a highly successful doctoral degree program in pharmacology, the goal of which is to recruit and train research leaders at the intersection of chemistry, biology, and medicine. The program fosters the development of independent Ph.D. investigators with expertise in the design and characterization of therapeutic agents and the study of their effects on living systems. Interdisciplinary training includes rigorous didactic teaching and intensive research training. Core courses in bioorganic chemistry, structural biology, biochemistry, molecular biology, cell biology, and bioinformatics provide students with the fundamental concepts of biomedical science. Our Graduate Pharmacology course teaches the quantitative foundations of pharmacology and the mechanisms of drug actions. Small group tutorials provide in-depth exploration of specific interest areas, and elective courses support focused training in areas ranging from analytical chemistry to clinical pharmacology. Students initiate research upon entering the program, performing laboratory research rotations in their first year in advance of selecting a thesis research advisor. Under the guidance of their thesis advisory committee, students execute significant research in the laboratory of one of 36 program faculty, each of whom direct well-supported vigorous research programs. Doctoral research areas include drug design, protein structure and function, glycobiology and lipid function, molecular imaging, virology, microbiology, immunology, oncology, and neuropharmacology. Students participate as speakers in pharmacology research seminars, journal clubs, and laboratory meetings, and are encouraged to present their studies at national and international meetings. After completing their thesis research, students write a doctoral thesis, critiqued by their thesis advisory committee, prior to presenting their doctoral studies at a public seminar. The program, established in 1969 and funded by the NIH since 1978, has awarded nearly 150 PhD degrees. There are 39 trainees currently in the program, and 15 more confirmed for matriculation this summer. Enrollment averaged 11 per year for the past 5 years (range 7-15). Students typically obtain their Ph.D. degrees within 4-6 years. The training facilities include departmental and institutional classrooms, seminar rooms, lecture halls, and libraries, and the well equipped laboratories of the 36 faculty located at Johns Hopkins Schools of Medicine, Public Health, and Arts and Sciences. High-end analytical instrumentation including robotic high-throughput screening, high-end and walk-up mass spectrometers, and an 800 MHz NMR are available for student research. Students in the program have contributed meaningfully to biomedical discovery over the last decades, and graduates of the program hold research, teaching, and leadership positions throughout the world in top academic, industrial, and government institutions.