TRAINING TO IMPROVE CARDIOVASCULAR DRUG THERAPY

描述（由申请人提供）： 该计划的目标是培养有前途的新科学家的机制， 心血管疾病，必要的实验策略和技术 用于开发新的分子疗法。 节目的主题是 在一个多学科的信号转导，综合方案， 重点关注心脏和血管发育，高血压， 参与心肌肥大和衰竭的基因/蛋白质，传导 信号分子和信号传导的结构和功能异常 血管平滑肌、心肌细胞和传导组织中的事件。 培训资源包括分子遗传学与转基因和敲除 设备、显微镜、图像分析、质谱和应用 化学. 进入博士预科生的指导方针包括学士学位 学位，GRE成绩，有研究经验的推荐信 preferred. 进入博士后培训生的指导方针包括博士学位。 和/或医学博士学位;先前的研究经验和推荐信。 我们重视具有不同背景的学员。 需要财政支持 2、4、6、6、6、8名博士后研究生/年， 年26-30。 培训参与者是药理学，医学和生物医学系的教师 （心脏病学，内分泌学，流变学），细胞生物学和解剖学， 生物化学、生理学和外科学。 博士前培训生进入 生物医学科学第一年课程，然后加入心血管 生物学跟踪在他们的第二年作为细胞和分子的一部分 药理学和实验治疗学博士课程或细胞和 分子生物学和病理生物学博士程序. 此后，他们 心血管生物学的高级课程和他们所要求的课程 个人博士学位计划并开展他们的论文研究。 博士后培训强调实验室研究， 和高级课程。 所有博士预科生 和博士后学员会见来访的科学家，在当地 研讨会和国家会议，并参加联合期刊俱乐部， 研讨会等 我们的目标是培养出具有广泛知识的杰出调查人员。 深入了解心血管功能障碍， 有助于了解这些疾病和发展 治疗心血管疾病。

DESCRIPTION (provided by applicant): The program objective is to train promising new scientists in mechanisms of cardiovascular diseases, experimental strategies and technologies necessary for development of novel molecular therapeutics. The theme of the program is signal transduction within a multidisciplinary, integrated program that focuses on events involved in cardiac and vascular development, hypertension, genes/proteins involved in myocardial hypertrophy and failure, conduction abnormalities, structure and function of signaling molecules and signaling events in vascular smooth muscle, cardiac myocytes and conducting tissue. Training resources include molecular genetics with transgenic and knockout facilities, microscopy, image analysis, mass spectrometry and applied chemistry. Guidelines for entering predoctoral trainees include baccalaureate degree, GRE scores, letters of recommendation with prior research experience preferred. Guidelines for entering postdoctoral trainees include the Ph.D. and/or M.D. degrees; prior research experience and letters of recommendation. We value trainees with diverse backgrounds. Financial support is requested for 2, 4, 6, 6, 6, predoctoral trainees and 8 postdoctoral trainees/year for years 26-30. Training participants are faculty in Pharmacology, Medicine (Cardiology, Endocrinology, Rheumatology), Cell Biology and Anatomy, Biochemistry, Physiology and Surgery. Predoctoral trainees enter the Biomedical Sciences First Year Curriculum and then join the Cardiovascular Biology track in their second year as part of the Cell and Molecular Pharmacology and Experimental Therapeutics Ph.D program or the Cell and Molecular Biology and Pathobiology Ph.D. program. Thereafter, they take advanced courses in cardiovascular biology and those required by their individual Ph.D. program and carry out their dissertation research. Postdoctoral training emphasizes laboratory investigation with access to basic and advanced courses. All predoctoral and postdoctoral trainees meet with visiting scientists, present at local seminars and national meetings, and participate in joint journal clubs and seminars. Our aim is to produce outstanding investigators with a broad insight into cardiovascular dysfunction who will make significant contributions to the understanding of these disorders and development of therapies for cardiovascular diseases.