Training To Improve Cardiovascular Therapies
Training To Improve Cardiovascular Therapies
批准号:
10219326
负责人:
Donald R. Menick
金额:
$56.08万
依托单位国家:
美国
项目类别:
财政年份:
1977
资助国家:
美国
项目状态:
已结题
起止时间:
1977-07-01 至 2023-06-30
中文摘要
点击翻译按钮获取中文摘要
英文摘要
PROJECT SUMMARY / ABSTRACT
The program objective is to train promising new scientists in mechanisms of cardiovascular diseases,
experimental strategies and technologies necessary for development of novel molecular therapeutics. The
theme of the program is signal transduction within a multidisciplinary, integrated program that focuses on
molecular events in cardiovascular development, proteomics, cardiac stem cells and regenerative medicine as
well as the molecular basis of cardiovascular disease. Future decades will see rapid advances in our
understanding of the structure and function of molecules involved in cardiovascular disease and hopefully the
successful application of these insights into the development of novel treatments and prevention of
cardiovascular diseases. Such advances will require well-trained, energetic and productive scientists with the
ability to understand and manipulate molecular events within a physiological context. These are the type of
individuals that we intend to develop through the integrated predoctoral and postdoctoral components of this
training program. The 29 mentor-eligible faculty members were selected on the basis of their research
interests related to cardiovascular diseases, active NIH research support, ongoing collaborations, successful
training and mentoring experience, and commitment to predoctoral and postdoctoral training. The Program
Director and Associate Director are assisted by a Program Steering Committee and an External Advisory
Committee of outstanding experts in the field of cardiovascular biology. Key components of the training
program are the mentor research experience, required didactic courses providing a broad perspective of
cardiovascular disease, required training and responsible conduct of research, elective courses, cardiovascular
journal club, seminars, presentations at regional and national conferences, and professional development
activities. The cardiovascular courses, journal club, seminars, workshops, student research day, and annual
cardiovascular retreat provide a framework for all trainees to interact, collaborate, and work together during
their training experience. An integrative, multi-year evaluation plan is used to measure the extent to which the
program goals and objectives are met. Our aim is to produce outstanding investigators with a broad insight
into cardiovascular dysfunction who make significant contributions to the understanding of these disorders and
development of therapies for cardiovascular diseases.
期刊论文(20)
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DOI:
10.1371/journal.pone.0264413
发表时间:
2022
期刊:
PloS one
影响因子:
3.7
作者:
[Reese CF, Chinnakkannu P, Tourkina E, Hoffman S, Kuppuswamy D]
通讯作者:
Kuppuswamy D
Effect of R(+)alpha-lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes.
R( )α-硫辛酸对大鼠肝细胞丙酮酸代谢和脂肪酸氧化的影响。
DOI:
10.1016/j.metabol.2003.09.008
发表时间:
2004
期刊:
Metabolism: clinical and experimental
影响因子:
--
作者:
[Walgren,JennieL, Amani,Zainab, McMillan,JoEllynM, Locher,Mathias, Buse,MariaG]
通讯作者:
Buse,MariaG
Increased expression of estrogen-related receptor β during adaptation of adult cardiomyocytes to sustained hypoxia.
成年心肌细胞适应持续缺氧过程中雌激素相关受体β表达增加。
DOI:
--
发表时间:
2016
期刊:
American journal of cardiovascular disease
影响因子:
1.3
作者:
[Cunningham,KathrynF, Beeson,GydaC, Beeson,CraigC, McDermott,PaulJ]
通讯作者:
McDermott,PaulJ
DOI:
10.1186/s13019-021-01743-0
发表时间:
2021-12-28
期刊:
Journal of cardiothoracic surgery
影响因子:
1.6
作者:
[Kwon JH, Hill M, Gerry B, Kubalak SW, Mohiuddin M, Kavarana MN, Rajab TK]
通讯作者:
Rajab TK
Characterization of a regulated form of phospholipase D in the yeast Saccharomyces cerevisiae.
酿酒酵母中磷脂酶 D 调节形式的表征。
DOI:
10.1042/bj3070799
发表时间:
1995
期刊:
The Biochemical journal
影响因子:
--
作者:
[Ella,KM, Dolan,JW, Meier,KE]
通讯作者:
Meier,KE
共 11 条
ShEEP application for Integrated Hypoxia Exposure and Analysis Core
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批准号:9795680
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项目类别:
-
资助金额:$0.0万
-
财政年份:2019
-
负责人:Donald R. Menick
-
依托单位:
Regulatory Role of HDAC in Post-MI Ventricular Remodeling
-
批准号:9919999
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Donald R. Menick
-
依托单位:
Regulatory Role of HDAC in Post-MI Ventricular Remodeling
-
批准号:10265359
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Donald R. Menick
-
依托单位:
Regulatroy Role of HDAC in Post-MI Ventricular Remodeling
-
批准号:8818507
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项目类别:
-
资助金额:$0.0万
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财政年份:2014
-
负责人:Donald R. Menick
-
依托单位:
Regulatory Role of HDAC in Post-MI Ventricular Remodeling
-
批准号:10455524
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项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Donald R. Menick
-
依托单位:
Regulatory Role of HDAC in Post-MI Ventricular Remodeling
-
批准号:10830235
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项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Donald R. Menick
-
依托单位:
Regulatroy Role of HDAC in Post-MI Ventricular Remodeling
-
批准号:8975085
-
项目类别:
-
资助金额:$0.0万
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财政年份:2014
-
负责人:Donald R. Menick
-
依托单位:
MAP4 REGULATION OF CARDIAC MICROTUBULE NETWORK DENSITY
-
批准号:8639216
-
项目类别:
-
资助金额:$5.72万
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财政年份:2010
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负责人:Donald R. Menick
-
依托单位:
MAP4 REGULATION OF CARDIAC MICROTUBULE NETWORK DENSITY
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批准号:8235944
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项目类别:
-
资助金额:$36.51万
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财政年份:2010
-
负责人:Donald R. Menick
-
依托单位:
MAP4 REGULATION OF CARDIAC MICROTUBULE NETWORK DENSITY
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批准号:8490586
-
项目类别:
-
资助金额:$34.75万
-
财政年份:2010
-
负责人:Donald R. Menick
-
依托单位:
Research Education Program for Minority Medical Students
-
批准号:8829317
-
项目类别:
-
资助金额:$9.05万
-
财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
Role of Protein Acetylation in Ncx1 Expression
-
批准号:8241023
-
项目类别:
-
资助金额:$36.51万
-
财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
Research Education Program for Minority Medical Students
-
批准号:8244458
-
项目类别:
-
资助金额:$10.74万
-
财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
Research Education Program for Minority Medical Students
-
批准号:8447024
-
项目类别:
-
资助金额:$10.74万
-
财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
Research Education Program for Minority Medical Students
-
批准号:7797604
-
项目类别:
-
资助金额:$10.74万
-
财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
Research Education Program for Minority Medical Students
-
批准号:8616518
-
项目类别:
-
资助金额:$9.05万
-
财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
Research Education Program for Minority Medical Students
-
批准号:8047951
-
项目类别:
-
资助金额:$10.74万
-
财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
Role of Protein Acetylation in Ncx1 Expression
-
批准号:7634185
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项目类别:
-
资助金额:$36.88万
-
财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
Role of Protein Acetylation in Ncx1 Expression
-
批准号:7810659
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项目类别:
-
资助金额:$36.88万
-
财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
Role of Protein Acetylation in Ncx1 Expression
-
批准号:8052748
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项目类别:
-
资助金额:$36.88万
-
财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
海外基金