Training To Improve Cardiovascular Therapies
Training To Improve Cardiovascular Therapies
批准号:
10219326
负责人:
Donald R. Menick
金额:
$56.08万
依托单位国家:
美国
项目类别:
财政年份:
1977
资助国家:
美国
项目状态:
已结题
起止时间:
1977-07-01 至 2023-06-30
中文摘要
项目摘要://摘要:
--
该计划的目标是帮助培训一批在心血管疾病的发病机制方面有前途的新科学家。
实验药物战略和技术是开发新型分子药物疗法所必需的。
该项目的主题是在一个多学科的、综合的、以信息为重点的项目中实现信号和信号的转导。
分子生物学事件涉及心血管疾病的发展、蛋白质组学、心脏干细胞和再生医学等。
以及心血管疾病的分子生物学基础。在未来的几十年里,我们的心脏将不会有快速的进步。
了解这些分子的结构和功能有助于心血管疾病的治疗,并有望为临床治疗提供帮助。
这些洞察力的成功应用有助于进一步开发新的治疗方法和预防癌症的新方法。
心血管疾病。要取得这样的进展,将不需要训练有素、精力充沛、工作效率高的科学家与他们合作。
在一个生理环境中能够理解和操纵分子生物学事件的能力。这是一种特殊类型的生物学。
个人表示,我们可能打算通过中国博士后教育和博士后教育的综合组成部分来推动教育的发展。
培训计划。所有29名符合导师资格的教师和成员都是在完成他们的研究的基础上被最终挑选出来的。
与心血管疾病相关的兴趣,积极参与NIH的研究和支持,以及正在进行的研究合作,并取得成功。
培训和指导包括经验、技能和承诺,包括博士后培训和博士后培训。
主任和副主任由一个指导委员会的项目和一个外部环境咨询机构提供协助。
由一批杰出的医学专家组成的委员会致力于心血管和生物学领域的研究。他们是医学培训的关键组成部分。
他们是研究和经验的最佳导师,也是必要的教学课程,为学生提供了一个非常广阔的视角。
心血管疾病,需要培训人员和负责进行临床研究、选修课和心血管疾病培训的人。
杂志、俱乐部、研讨会、在地区会议和国家会议上的演讲、信息和专业技术发展。
活动。包括心血管疾病课程、大学杂志和俱乐部、大学研讨会、大学工作坊、学生研究每天、一周和一年一次。
心血管疾病培训为所有学员提供了一个良好的框架,让他们在培训期间能够更好地互动、协作、沟通和合作。
他们的培训和经验。他们是一个综合的、多年的评估和计划,通常被用来衡量他们的培训程度。
项目的目标和目标都没有实现。我们的目标是培养出一批具有广泛的社会洞察力的优秀的中国调查人员。
谁能对心血管疾病做出重大贡献,谁就会对这些疾病有更深入的了解。
治疗心血管疾病的新疗法的发展趋势。
英文摘要
PROJECT SUMMARY / ABSTRACT
The program objective is to train promising new scientists in mechanisms of cardiovascular diseases,
experimental strategies and technologies necessary for development of novel molecular therapeutics. The
theme of the program is signal transduction within a multidisciplinary, integrated program that focuses on
molecular events in cardiovascular development, proteomics, cardiac stem cells and regenerative medicine as
well as the molecular basis of cardiovascular disease. Future decades will see rapid advances in our
understanding of the structure and function of molecules involved in cardiovascular disease and hopefully the
successful application of these insights into the development of novel treatments and prevention of
cardiovascular diseases. Such advances will require well-trained, energetic and productive scientists with the
ability to understand and manipulate molecular events within a physiological context. These are the type of
individuals that we intend to develop through the integrated predoctoral and postdoctoral components of this
training program. The 29 mentor-eligible faculty members were selected on the basis of their research
interests related to cardiovascular diseases, active NIH research support, ongoing collaborations, successful
training and mentoring experience, and commitment to predoctoral and postdoctoral training. The Program
Director and Associate Director are assisted by a Program Steering Committee and an External Advisory
Committee of outstanding experts in the field of cardiovascular biology. Key components of the training
program are the mentor research experience, required didactic courses providing a broad perspective of
cardiovascular disease, required training and responsible conduct of research, elective courses, cardiovascular
journal club, seminars, presentations at regional and national conferences, and professional development
activities. The cardiovascular courses, journal club, seminars, workshops, student research day, and annual
cardiovascular retreat provide a framework for all trainees to interact, collaborate, and work together during
their training experience. An integrative, multi-year evaluation plan is used to measure the extent to which the
program goals and objectives are met. Our aim is to produce outstanding investigators with a broad insight
into cardiovascular dysfunction who make significant contributions to the understanding of these disorders and
development of therapies for cardiovascular diseases.
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DOI:
10.1371/journal.pone.0264413
发表时间:
2022
期刊:
PloS one
影响因子:
3.7
作者:
[Reese CF, Chinnakkannu P, Tourkina E, Hoffman S, Kuppuswamy D]
通讯作者:
Kuppuswamy D
Effect of R(+)alpha-lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes.
R( )α-硫辛酸对大鼠肝细胞丙酮酸代谢和脂肪酸氧化的影响。
DOI:
10.1016/j.metabol.2003.09.008
发表时间:
2004
期刊:
Metabolism: clinical and experimental
影响因子:
--
作者:
[Walgren,JennieL, Amani,Zainab, McMillan,JoEllynM, Locher,Mathias, Buse,MariaG]
通讯作者:
Buse,MariaG
Increased expression of estrogen-related receptor β during adaptation of adult cardiomyocytes to sustained hypoxia.
成年心肌细胞适应持续缺氧过程中雌激素相关受体β表达增加。
DOI:
--
发表时间:
2016
期刊:
American journal of cardiovascular disease
影响因子:
1.3
作者:
[Cunningham,KathrynF, Beeson,GydaC, Beeson,CraigC, McDermott,PaulJ]
通讯作者:
McDermott,PaulJ
DOI:
10.1186/s13019-021-01743-0
发表时间:
2021-12-28
期刊:
Journal of cardiothoracic surgery
影响因子:
1.6
作者:
[Kwon JH, Hill M, Gerry B, Kubalak SW, Mohiuddin M, Kavarana MN, Rajab TK]
通讯作者:
Rajab TK
Characterization of a regulated form of phospholipase D in the yeast Saccharomyces cerevisiae.
酿酒酵母中磷脂酶 D 调节形式的表征。
DOI:
10.1042/bj3070799
发表时间:
1995
期刊:
The Biochemical journal
影响因子:
--
作者:
[Ella,KM, Dolan,JW, Meier,KE]
通讯作者:
Meier,KE
共 11 条
ShEEP application for Integrated Hypoxia Exposure and Analysis Core
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批准号:9795680
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项目类别:
-
资助金额:$0.0万
-
财政年份:2019
-
负责人:Donald R. Menick
-
依托单位:
Regulatory Role of HDAC in Post-MI Ventricular Remodeling
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批准号:9919999
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Donald R. Menick
-
依托单位:
Regulatory Role of HDAC in Post-MI Ventricular Remodeling
-
批准号:10265359
-
项目类别:
-
资助金额:$0.0万
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财政年份:2014
-
负责人:Donald R. Menick
-
依托单位:
Regulatroy Role of HDAC in Post-MI Ventricular Remodeling
-
批准号:8818507
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项目类别:
-
资助金额:$0.0万
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财政年份:2014
-
负责人:Donald R. Menick
-
依托单位:
Regulatory Role of HDAC in Post-MI Ventricular Remodeling
-
批准号:10455524
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Donald R. Menick
-
依托单位:
Regulatory Role of HDAC in Post-MI Ventricular Remodeling
-
批准号:10830235
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项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Donald R. Menick
-
依托单位:
Regulatroy Role of HDAC in Post-MI Ventricular Remodeling
-
批准号:8975085
-
项目类别:
-
资助金额:$0.0万
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财政年份:2014
-
负责人:Donald R. Menick
-
依托单位:
MAP4 REGULATION OF CARDIAC MICROTUBULE NETWORK DENSITY
-
批准号:8639216
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项目类别:
-
资助金额:$5.72万
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财政年份:2010
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负责人:Donald R. Menick
-
依托单位:
MAP4 REGULATION OF CARDIAC MICROTUBULE NETWORK DENSITY
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批准号:8235944
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项目类别:
-
资助金额:$36.51万
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财政年份:2010
-
负责人:Donald R. Menick
-
依托单位:
MAP4 REGULATION OF CARDIAC MICROTUBULE NETWORK DENSITY
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批准号:8490586
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项目类别:
-
资助金额:$34.75万
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财政年份:2010
-
负责人:Donald R. Menick
-
依托单位:
Research Education Program for Minority Medical Students
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批准号:8829317
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项目类别:
-
资助金额:$9.05万
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财政年份:2009
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负责人:Donald R. Menick
-
依托单位:
Research Education Program for Minority Medical Students
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批准号:8244458
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项目类别:
-
资助金额:$10.74万
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财政年份:2009
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负责人:Donald R. Menick
-
依托单位:
Role of Protein Acetylation in Ncx1 Expression
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批准号:8241023
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项目类别:
-
资助金额:$36.51万
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财政年份:2009
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负责人:Donald R. Menick
-
依托单位:
Research Education Program for Minority Medical Students
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批准号:8447024
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项目类别:
-
资助金额:$10.74万
-
财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
Research Education Program for Minority Medical Students
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批准号:7797604
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项目类别:
-
资助金额:$10.74万
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财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
Research Education Program for Minority Medical Students
-
批准号:8616518
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项目类别:
-
资助金额:$9.05万
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财政年份:2009
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负责人:Donald R. Menick
-
依托单位:
Research Education Program for Minority Medical Students
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批准号:8047951
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项目类别:
-
资助金额:$10.74万
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财政年份:2009
-
负责人:Donald R. Menick
-
依托单位:
Role of Protein Acetylation in Ncx1 Expression
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批准号:7634185
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项目类别:
-
资助金额:$36.88万
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财政年份:2009
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负责人:Donald R. Menick
-
依托单位:
Role of Protein Acetylation in Ncx1 Expression
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批准号:7810659
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项目类别:
-
资助金额:$36.88万
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财政年份:2009
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负责人:Donald R. Menick
-
依托单位:
Role of Protein Acetylation in Ncx1 Expression
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批准号:8052748
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项目类别:
-
资助金额:$36.88万
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财政年份:2009
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负责人:Donald R. Menick
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依托单位:
海外基金