Chiral lewis Base-Catalyzed Asymmetric Reactions

描述：（申请人描述）本研究的长期目标 计划是开发高效，可靠和实用的催化不对称 反应，这将提供合成化学家在学术界和工业界 与必要的工具，设计高效，实用和环保 合成药物和其他生物活性物质的友好途径 活性化合物我们努力实现这一目标， 开发容易获得的手性催化剂和广泛探索 它们促进催化不对称反应的能力。具体来说，我们将 专注于开发易于获得的手性刘易斯碱催化剂， 广泛的不对称亲核-亲电反应， 它结合了广泛的反应筛选，密集的开发和 优化了反应条件，并考虑了反应机理和结构 问题研究为了说明这些不对称反应在 生物医学研究，我们概述了利用这些不对称的合成路线， 将容易获得的前手性前体转化成各种 用于不对称合成的光学活性手性结构单元 生物学上有趣的化合物。

DESCRIPTION: (Applicant's Description) The long-term goal of this research program is to develop efficient, reliable and practical catalytic asymmetric reactions, which will provide synthetic chemists in both academia and industry with the necessary tools to design efficient, practical and environmentally friendly routes for the synthesis of pharmaceuticals and other biologically active compounds. We strive to achieve this goal through the discovery and development of readily accessible chiral catalysts and a broad exploration of their ability to promote catalytic asymmetric reactions. Specifically we will focus on the development of readily available chiral Lewis base catalysts for a wide range of asymmetric nucleophile-electrophile reactions via an approach that combines extensive reaction screening, intensive development and optimization of reaction conditions, and thoughtful mechanistic and structural studies. To illustratethe potential usefulness of these asymmetric reactions in biomedical research, we outline synthetic routes which utilize these asymmetric reactions to transform readily available prochiral precursors into various optically active chiral building blocks for asymmetric synthesis of biologically interesting compounds.