Targeting metabolism in the tumour microenvironment in ovarian high grade serous carcinoma (HGSC)

研究代谢对卵巢高级别浆液性癌（HGSC）免疫抑制肿瘤微环境的贡献，以确定治疗机会。她将测试针对脂质、乳酸或NAD代谢的不同代谢抑制剂的能力，以使HGSC小鼠模型对AKTi、PARPi、抗vegf和免疫治疗敏感，同时在具有不同遗传背景的同基因HGSC小鼠模型中描述与基因型、结果和治疗反应相关的代谢表型。她的研究还将涉及确定HGSC中负责药物反应调节的因果代谢途径。

Investigating the contribution of metabolism to the immunosuppressive tumour microenvironment in ovarian high grade serous carcinoma (HGSC) to identify therapeutic opportunities. She will be testing the ability of different metabolic inhibitors that target either lipid, lactate or NAD metabolism to sensitise HGSC mouse models to AKTi, PARPi, anti-VEGF and immunotherapy, whilst characterising the metabolic phenotypes associated with genotype, outcomes and therapy response in syngeneic HGSC mouse models with varying genetic backgrounds. Her research will also involve identifying the causal metabolic pathways responsible for drug response modulation in HGSC.