TRAINING IN MOLECULAR RHEUMATOLOGY AND ORTHOPEDICS

描述(由申请人提供)： 本申请书请求支持继续1994年启动的培训计划，该计划致力于对以下人员进行严格培训：(1)已完成风湿病学或骨科学科临床培训的上进心强的医生；(2)在骨科培训期间选择获得博士学位的医生；(3)新近毕业的博士。S致力于从事风湿病或骨科疾病的研究；以及(4)希望从事人类临床研究事业的风湿病医生。该计划提供密切监督的密集实验室经验，强调应用最先进的分子生物学、遗传学、细胞生物学和生物化学方法来研究影响结缔组织和肌肉骨骼系统的疾病的病因和发病机制。该计划还在进行人类临床调查研究方面提供严格的培训。这一培训计划的主要优势是：(1)对影响到大部分人口的具有重大公共卫生和社会经济重要性的疾病的研究采取综合和多学科的方法；(2)高生产率和有成就的培训人员队伍；(3)教员专业知识和研究兴趣的多样性，以及他们应用最先进的分子生物学方法研究各种风湿和肌肉骨骼疾病；(4)教员长期致力于内科科学家和博士S的培训；以及(5)我们机构最近设立了由美国国立卫生研究院支持的人类临床研究课程。培训计划将我们研究所以前正在进行的各种培训活动整合为一个统一的计划，高度专注于风湿性和肌肉骨骼疾病的病因和发病机制的研究，以及获得进行风湿性和肌肉骨骼疾病的人类临床调查的培训和技能。提供的培训机会具有统一的目标，即使受训者准备好将分子生物学、遗传学、细胞生物学、生物化学和人类临床调查的最先进方法应用于研究影响肌肉骨骼系统的广泛疾病。项目完成后，学员将为获得学术任命和从事内科科学家、临床研究人员或博士的职业生涯做好充分准备。S有能力在风湿学和骨科相关领域建立独立的研究项目。

DESCRIPTION(Provided by Applicant): This is an application requesting support to continue a Training Program initiated in 1994 devoted to the rigorous training of: (1) highly motivated physicians who have completed their clinical training in the disciplines of Rheumatology or Orthopedics; (2) physicians who have chosen to obtain a Ph.D. degree during their training in Orthopedics; (3) recently graduated Ph.D.'s committed to conduct research applicable to Rheumatology or Orthopedic diseases; and (4) Rheumatologists wishing to pursue a career in Human Clinical Investigation. The program provides closely supervised intensive laboratory experience emphasizing the application of state of the art methods of Molecular Biology, Genetics, Cell Biology and Biochemistry towards the investigation of the etiology and pathogenesis of diseases affecting the connective tissues and the musculoskeletal system. The program also provides rigorous training in the conduct of human clinical investigation studies. The major strengths of this Training Program are: (1) the comprehensive and multidisciplinary approach to the study of disorders of great public health and socioeconomic importance which affect a large segment of the population; (2) the cadre of highly productive and accomplished trainors, (3) the diverse nature of the expertise and research interests of the faculty and their application of the most advanced molecular biological approaches to the study of various rheumatic and musculoskeletal diseases; (4) the long-term commitment of the faculty to the training of Physician Scientists and Ph.D.'s; and (5) the recent establishment at our institution of an NIH-supported Human Clinical Investigation Curriculum. The Training Program consolidates various training activities previously ongoing at our Institution into a unified program which is highly focused on the study of the etiology and pathogenesis of rheumatic and musculoskeletal diseases and on the acquisition of training and skills for the conduct of Human Clinical Investigation in the rheumatic and musculoskeletal diseases. The training opportunities offered have the unifying goal of preparing the trainees in the application of the most advanced methods of Molecular Biology, Genetics, Cell Biology, Biochemistry and Human Clinical Investigation to the study of a broad spectrum of diseases affecting the musculoskeletal system. At the completion of the program, the trainees will be well prepared to obtain academic appointments and to pursue careers as Physician-Scientists, Clinical Investigators or as Ph.D.'s capable of establishing independent research programs in areas relevant to Rheumatology and Orthopedics.