Conference on Drugs Against Protozoan Parasites

描述（由申请人提供）：本提案旨在请求支持将于2005年4月9日至4月13日在铜山举行的题为“抗原生动物寄生虫药物：目标选择、结构生物学和药物化学”的关键会议。会议将讨论寄生虫药物开发方面的重要问题。全世界有数亿人患有由原生动物寄生虫引起的疾病。缺乏治疗昏睡病和利什曼病的有效药物，目前治疗疟疾的疗法由于耐药性而面临风险。因此，迫切需要开发新的抗原生动物剂。随着疟疾、昏睡病和利什曼病的生物体基因组测序的完成，这是发现和评估新药物靶点的一个激动人心的时刻，特别是当与结构生物学、组合化学和寄生虫遗传学相结合时。由化学家、结构生物学家和寄生虫学家组成的小组将展示多学科合作的力量。还邀请了寄生虫学以外的药物开发专家，以激发他们对热带医学的兴趣，并学习他们的经验。

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone meeting entitled "Drugs Against Protozoan Parasites: Target Selection, Structural Biology and Medicinal Chemistry", which will be held in Copper Mountain from April 9 - April 13, 2005. The meeting will address important issues in parasite drug development. Hundreds of millions of people worldwide suffer from diseases caused by protozoan parasites. Effective drugs are lacking for sleeping sickness and leishmaniasis, and current therapies for treating malaria are at risk due to drug resistance. Thus, the development of new lines of anti-protozoan agents is urgently needed. With the sequencing of genomes of organisms responsible for malaria, sleeping sickness, and leishmaniasis, this is an exciting time for the discovery and evaluation of new drug targets, especially when combined with structural biology, combinatorial chemistry, and parasite genetics. Groups of talks, given by chemists, structural biologists, and parasitologists, will exemplify the power of multi-disciplinary collaborations. Experts in drug development outside of parasitology have also been invited in an effort to stimulate their interests in tropical medicine and to learn from their experiences.