FASEB Conference: Skeletal muscle satellite/stem cells

描述(由申请人提供)：本申请寻求对即将于2005年6月11日至16日在亚利桑那州图森市举行的名为骨骼肌卫星和干细胞的美国实验生物学联合会(FASE B)会议的部分支持。本次会议的总体目标是强调与肌源性干细胞和祖细胞群体(如卫星细胞)的调控机制有关的最新进展，以及它们在发育、再生、衰老和肌病状态中的作用。这将是该领域的第四次会议，从第一次会议到第三次会议的参与人数增加，表明需要专门讨论卫星和干细胞问题的会议。从前三次会议的成功中可以清楚地看出，这一专题引起了高度关注，而这次会议是唯一一次直接讨论肌肉、卫星和干细胞群体问题的会议。本次论坛将侧重于鉴定成人骨骼肌中的祖细胞/干细胞群体，特别关注它们在发育、肥大、再生、衰老和疾病中的作用。讨论将针对基于细胞的疗法的平台。 本次会议的会议内容包括：卫星细胞与发育、卫星细胞多样性、卫星细胞周期控制与信号、干细胞生物学与治疗策略、卫星细胞生长/细胞外基质/生物工程、成人肌源性干细胞、骨骼肌肥大与再生、衰老、肌肉疾病和干细胞治疗研讨会。重要的是，这次会议的与会者将代表跨学科小组，他们将为该领域的最新发现提供全面的分析和整合。这次会议将进一步促进协作互动，试图促进未来针对治疗和治愈肌病患者的进展和翻译倡议。

DESCRIPTION (provided by applicant): This application seeks partial support for the upcoming Federation of American Societies of Experimental Biology (FASEB) conference entitled, Skeletal muscle satellite and stem cells that will be held on June 11- 16, 2005 in Tucson, AZ. The overall objective of this meeting is to highlight recent advances pertaining to the regulatory mechanisms of myogenic stem cell and progenitor cell populations (such as satellite cells) and their role in development, regeneration, aging and myopathic states. This will be the fourth conference for this field and the increased participation from the first to the third meeting demonstrates the need for a conference dedicated to satellite and stem cells. It is clear from the successes of the previous three meetings that this topic is of high interest and this meeting represents the only conference that directly addresses muscle satellite and stem cell populations. This forum will focus on the identification of the progenitor/stem cell populations that are resident in adult skeletal muscle with a particular focus on their participation in development, hypertrophy, regeneration, aging and disease. Discussion will be directed toward platforms for cell based therapies. The sessions of this conference include: satellite cells and development, satellite cell diversity, satellite cell cycle control and signaling, stem cell biology and therapeutic strategies, satellite cell growth/ECM/ Bioengineering, myogenic stem cells in adults, skeletal muscle hypertrophy and regeneration, aging, muscle diseases and a stem cell therapy workshop. Importantly, the participants of this conference will represent interdisciplinary groups that will provide a comprehensive analysis and integration of recent discoveries for the field. The conference will further promote collaborative interactions in an attempt to promote future advancements and translational initiatives directed toward the treatment and cure of patients with myopathic diseases.