Cooperation among subcortical networks underlying memory

描述(申请人提供)：海马体在记忆中的作用是 以及与大脑皮质下结构相连的重要性。 自从Korsakoff和Wernike的开创性工作以来，海马体就已经为人所知。 尽管某些内存不足最好地用 间脑-海马体综合征，几乎什么都不知道 前脑系统之间的相互作用及其相互作用的方式 按脑干组织的，以说明依赖于强健状态的 改变潜在的学习和记忆。 这个项目的中心焦点是海马区的皮质下调节。 函数，并遵循这样的一般假设，即此 调节不仅仅是将海马区的脑电在theta和 非theta模式，也是为了在几个 由theta节奏同步的边缘结构。海马区外 Theta活动最近在以下几个结构中得到了描述 乌拉坦麻醉，但从未在自然条件下。拟议的研究 将检验以下假设：(1)脑干/间脑系统 在theta和非theta之间切换参与与行为相关的罚款 自然theta状态下海马区活动的调节；(2)theta节律性 活动在不同边缘之间的神经元协作中起作用 显示theta节律性活动的结构和脑干结构 具体地调节这种流量；(3)在 隔和乳房复合体对乳房的反馈调节作用 脑干核团参与脑状态调节。 神经元活动的阶段性和节律性同步对 大脑中空间上分离的结构的协同作用。西塔 Synchrony提供了一个很好的模型来研究这种合作以及 这在特定的行为状态下是不同的。我们的实验将需要 将清醒的探索和睡眠作为一种自然的实验来尝试 请告诉我们记忆构建过程的组成部分。及时性 最近对这项工作的兴趣和数据链接的热潮突显了这项工作的重要性 睡眠、海马区活动和信息加工的连续时相 非快速眼动睡眠和快速眼动睡眠。

DESCRIPTION (provided by the applicant): The role of hippocampus in memory is well established and the importance of subcortical structures connected to the hippocampus has been known since the pioneering work of Korsakoff and Wernicke. Although certain memory deficits are best described in the frameworks of a diencephalo-hippocanipal syndrome, virtually nothing is known about how these forebrain systems interact with each other and how their interaction is organized by the brainstem so as to account for the robust state dependent changes underlying learning and memory. The central focus of this project is the subcortical regulation of hippocampal function and is guided by the general hypothesis that the role of this regulation is not only to switch the hippocampal EEG between theta and non-theta patterns but also to build dynamic associations between several limbic structures that are synchronized by the theta rhythm. Extrahippocampal theta activity has been recently described in a number of structures under urethane anesthesia but never under natural conditions. The proposed research will test the hypotheses that (1) brainstem/diencephalic systems, in addition to switching between theta and non-theta take part in behaviorally-related fine tuning of hippocampal activity during natural theta states; (2) theta rhythmic activity plays a role in neuronal cooperation between different limbic structures and brainstem structures exhibiting theta rhythmic activity specifically regulate this traffic; (3) theta rhythmic activity generated in the septum and the mammillaiy complex exerts feedback regulatory influence on brainstem nuclei involved in brain state regulation. Phasic and rhythmic synchronization of neuronal activity is critical to the concerted action of spatially separated structures in the brain. Theta synchrony provides an excellent model to study such cooperation and the way in which it differs in specific behavioral states. Our experiments will take advantage of waking exploration and sleep as a natural experiment trying to inform us about the components of the memory building process. The timeliness of this work is underlined by the recent upsurge of interest and data linking sleep, hippocampal activity and successive phases of information processing in non-REM and REM sleep.