Chiral Approaches to Natural Product Synthesis

描述：(申请人提供)本项目的长期目标 包括实验室合成具有以下特性的复杂天然产物 理想的生物活性以及新的合成方法的开发 将简化这项任务的方法。此外，我们计划尝试 鉴定、合成和测试这些天然存在的铅的类似物 可以更实际的方式综合访问的化合物 天然化合物本身。正在进行的关于全合成的研究 复杂的细胞毒性大二内酯Swinholide的研究将继续 有希望完成，对这种有希望的化合物的研究也将完成 其活性与紫杉醇相似。我们对生物多样性的研究 强大而极具前景的抗癌药物Bryostatin 1将继续存在，以及 我们希望将这一计划积极扩展到模拟合成领域。几种有机化合物的合成 白花丹内酯和多拉贝利B将启动，其类似物 银杏内酯将被制备用于抗真菌和细胞毒剂的检测。 在所有这些工作中，我们希望实现新的有机反应和 综合战略，将促进有针对性的建设 化合物，以及在更广泛的背景下证明是有用的。

DESCRIPTION: (provided by applicant) The long term goals of this program include the laboratory synthesis of complex natural products possessing desirable biological activity as well as the development of new synthetic methodology that will simplify this task. In addition, we plan to attempt to identify, and to synthesize and test, analogs of these naturally occurring lead compounds which can be accessed synthetically in a more practical manner than the natural compounds themselves. Ongoing investigations on the total synthesis of the complex cytotoxic macrodiolide swinholide will be continued and hopefully brought to completion, as will studies on the promising compound epothilone, which has activity similar to that of taxol. Our studies on the potent and extremely promising anticancer agent bryostatin 1 will continue, and we hope to expand this program aggressively into analog synthesis. Syntheses of leucascandrolide and dolabelide B will be initiated, and analogs of leucascandrolide will be prepared for assay as antifungal and cytotoxic agents. Throughout all of this work, we hope to implement new organic reactions and synthetic strategies which will facilitate the construction of the targeted compounds, as well as prove useful in a broader context.