Adiposity, Disease Risk Factors, and Lifetime Health

描述（由申请人提供）：这项拟议的研究建立在Fels纵向研究的工作基础上，这是一个独特的数据库，其中包含自1929年研究开始以来积累的新数据。Fels纵向研究是世界上最大和最长的连续系列研究，研究正常个体的生长，身体组成和成人慢性疾病的危险因素。我们的长期研究目标是确定身体组成成分（例如，脂肪组织、无脂肪质量）;更好地了解儿童和/或成人易患超重/肥胖、心血管疾病和其他衰老疾病的影响;并证明新的评估方法和统计方法的重要性，以更好地描述这些关系。 有两个一般目标，每个目标包含一组专注于分析序列数据的特定假设：1）使用在整个生命周期中收集的长期序列数据来确定身体组成、全身炎症因子、脂肪组织衍生的激素和常见复杂疾病的其他风险因素（例如，心血管疾病和肥胖）; 2）研究儿童期身体成分变化对成年期健康结果的影响。要解决的问题类型包括：身体成分的变化是否与同时或先前的成熟度、体力活动或心血管疾病的其他风险因素（例如，炎症标志物、血压、血脂或胰岛素抵抗）？危险因素的变化模式是否与脂肪组织分布有关？持续性超重/肥胖的发病年龄与后来心血管疾病风险因素水平之间的关系是什么？ 我们将继续量化身体成分，并评估与肥胖、炎症和其他疾病风险因素（例如，心血管疾病和糖尿病）。利用新的和现有的长期系列数据继续调查这些变量的变化性质和相互关系，将有助于澄清从儿童到老年早期慢性病的发病情况和风险因素。因此，在各种分析中将采用创新的分析方法。

DESCRIPTION (provided by applicant): This proposed research builds on the work of the Fels Longitudinal Study, a unique database that incorporates new data with that accumulated since the study began in 1929. The Fels Longitudinal Study is the world's largest and longest continuous serial study of growth, body composition and risk factors for adult chronic disease in normal individuals. Our long-term study goals are to identify the health effects of the amount and distribution of body composition components (e.g., adipose tissue, fat-free mass); to gain a better understanding of the influences that predispose individuals as children and/or adults to develop overweight/obesity, cardiovascular disease, and other diseases of aging; and to demonstrate the importance of new assessment methods and statistical approaches to describe these relationships better. There are two general aims, each encompassing a set of specific hypotheses focused on the analysis of serial data: l) to use long-term serial data collected throughout the life span to determine the nature of relationships among patterns of change in body composition, systemic inflammatory factors, adipose tissue-derived hormones, and other risk factors for common complex diseases (e.g., cardiovascular disease and obesity); and 2) to examine the effect of childhood changes in body composition on health outcomes in adulthood. Types of questions to be addressed include: Are changes in body composition related to concurrent or previous levels or patterns of change in maturity, physical activity, or other risk factors for cardiovascular disease (e.g., inflammatory markers, blood pressure, lipids, or insulin resistance)? Are patterns of change in risk factors related to adipose tissue distribution? What are the relationships between the age at onset of persistent overweight/obesity and later levels of risk factors for cardiovascular disease? We will continue to quantify body composition and to evaluate specific components related to adiposity, inflammation, and other risk factors for diseases (e.g., cardiovascular disease and diabetes). Continued investigation into the nature of changes in, and relationships among, these variables using new and existing long-term serial data will help to clarify the onset of, and risk factors for, chronic disease from childhood to early old age. Accordingly, innovative analytical approaches will be used in the various analyses.