Neural correlates of memory fMR in human cortex.

描述(由申请人提供)： 这项建议的总体目标是建立通过功能磁共振成像(FMR)获得的BOLD信号的变化与人类联想皮质中相同部位、相同受试者在相同认知测量期间神经元活动变化之间的关系。该提案利用了一个独特的临床机会，患者接受癫痫手术的技术是，他们在局部麻醉下清醒，进行部分手术。在此背景下，我们先前记录了在最近的言语记忆过程中，来自外侧颞叶联想皮质的神经元活动，包括动作电位(AP)和覆盖脑电(ECoG)，发现相当大比例的神经元在该任务中改变了AP活动的频率。Fmr文献和我们的初步Fmr数据都显示，随着最近的记忆测量，Fmr在外侧颞叶皮质中发生了变化。最近开发了一种既适用于FMR又适用于术中记录的言语记忆测量方法，我们建议研究AP、局部场电位(LFP)、ECoG和FMR之间的时空关系。有待检验的假设包括，基于非人类研究报告的结果，Fmr与LFP之间的关系比AP活动更密切，以及Fmr变化的特异性与记忆中AP活动的持续模式有关。这些研究提供了一个独特的窗口，了解在更高水平的认知测量中，神经活动如何反映在大胆的Fmr的变化中。

DESCRIPTION (provided by applicant): The overall aim of this proposal is to establish the relationships between changes in BOLD signals obtained with functional magnetic resonance imaging (fMR) and changes in activity of neurons during the same cognitive measures, at the same sites, in the same subjects in human association cortex. The proposal utilizes a unique clinical opportunity, patients undergoing surgery for epilepsy with a technique where they are awake under local anesthesia for a portion of the operation. In that context we have previously recorded neuronal activity, both action potentials (AP) and overlying electroencephalogram (ECoG) from lateral temporal association cortex during recent verbal memory, finding that a substantial proportion of neurons changed the frequency of AP activity with that task. Both the fMR literature and our preliminary fMR data show fMR changes in lateral temporal cortex with recent memory measures. Having developed a recent verbal memory measure suitable for both fMR and intraoperative recording, we propose investigating the spatial and temporal relation between AP, local field potential (LFP), ECoG and fMR. Hypotheses to be tested include a closer relation between fMR and LFP than AP activity, based on findings reported from nonhuman studies, and specificity of fMR changes to sites with sustained patterns of AP activity during memory. These studies provide a unique window into how neural activity is reflected in changes in BOLD fMR during higher-level cognitive measures.