Training in Mouse and Molecular Genetics of the Eye

描述(由申请人提供)：通过在分子水平上了解基因功能，生物医学科学已经发生了革命性的变化。实验室小鼠已经并将继续在阐明视觉系统正常发育和维持以及病理所涉及的基因功能和途径方面发挥关键作用。然而，几乎没有专门培训分子遗传学家使用小鼠模型进行视觉研究的项目。杰克逊实验室要求提供资金，以建立NEI的博士后培训计划，重点是视觉研究中的老鼠和分子遗传学。TJL研究人员的七名成员组成了一个跨学科的实习生教官队伍，他们正在使用经典和尖端的分子遗传学方法研究小鼠眼睛发育和可遗传眼部疾病的各个方面。在基因定义的动物模型中的实验工作提供了测试关于疾病的遗传基础的假说和模拟新的诊断和治疗模式的机会。由于实验室拥有无与伦比的特殊近亲繁殖、自发和诱变小鼠的资源库，这些类型的分析成为可能。 这一新的NEI培训补助金要求在头两年提供两个博士后职位，然后再申请三个博士后职位。学员主要致力于板凳研究，并融入TJL研讨会、课程、工作坊和研究兴趣小组。他们被要求撰写研究金申请，并每年在内部利益小组和国家或国际会议上提交结果。他们的进展由一个正式的培训委员会监督，每个成员都是几名受训人员的非正式导师或联络人。完成培训后，学员将有资格在大学、研究机构或行业从事创造性的、独立的视觉科学研究。 主要的培训设施是杰克逊实验室，这是一个私人的独立研究中心。TJL是NIH基础癌症研究中心，自1956年以来一直持有NIH研究培训补助金

DESCRIPTION (provided by applicant): Biomedical science has been revolutionized by understanding gene function at the molecular level. The laboratory mouse has and will continue to playa key role in elucidating gene function and pathways involved in normal development and maintenance, and pathology of the visual system. Yet there are few programs dedicated to training molecular geneticists in the use of mouse models for vision research. The Jackson Laboratory requests funding to establish a NEI postdoctoral training program focused on mouse and molecular genetics in vision research. Seven members of the TJL Research Staff form an interdisciplinary pool of trainee preceptors who are investigating various aspects of eye development and heritable ocular diseases in the mouse using classical and cutting edge molecular genetic approaches. Experimental work in genetically-defined animal models provides the opportunity to test hypotheses regarding the genetic basis of disorders and to model new diagnostic and therapeutic modalities. These types of analyses are made possible by the availability of the Laboratory's unparalleled resource base of special inbred, spontaneous and induced-mutant mice. This new NEI Training Grant requests two postdoctoral positions for the first two years and three, thereafter. Trainees devote their major effort to bench research, and are integrated into TJL seminars, courses, workshops, and research interest groups. They are required to write fellowship applications, and present their results annually, both at in-house interest groups and national or international meetings. Their progress is overseen by a formal Training Committee, each member of which acts as an informal mentor, or liaison, for several trainees. Upon completion of training, participants will be qualified to engage in creative, independent research in vision sciences at a university, research institution, or in industry. The primary training facility is The Jackson Laboratory, a private, independent research center. TJL is a NIH Basic Cancer Research Center, and has held NIH research training grants continuously since 1956