Research Training in Alimentary Tract Surgery

超出提供的空间。该计划为年轻外科医生提供研究培训，他们计划在消化道外科问题上为病人护理和调查职业生涯。它的主要目的是让这些人做好准备，成为独立资助的调查人员。该计划在分子和细胞生物学、生物化学和生物物理学、器官生理学和病理生理学以及免疫学的基础方面提供密集、协调的研究培训，因为它们适用于消化道、肝胆系统和胰腺疾病。该计划于1997年由布里格姆妇女医院的外科部门与前贝丝以色列医院合作设立，现已扩大到包括美国国立卫生研究院资助的哈佛医学院所有主要成人教学医院附属医院的外科研究实验室。核心教授小组目前的研究领域包括：1)胃肠粘膜分泌和屏障功能(Soybel，Hofer，Hagen)；2)败血症和休克时肝脏的能量和代谢紊乱(Fischer，Hasselgren)；3)饥饿或大规模切除后的肠道分化和生长反应(Hodin，Ashley，Zner)；4)急慢性胰腺炎的细胞生物学和病理生理学(Warshaw)；5)胰腺癌生长和转移的分子基础(Callery)；6)应用于消化道重建和康复的组织工程学(Vacanti，Wang)；7)消化系统手术的结果评估和新技术的引入(Zner，Warshaw，Daley)。此外，一些年轻的教员已经被招募到HMS的不同外科部门，打算将他们发展为GI和HPB外科领域的外科调查人员。我们建议在明确指定的情况下，让这些年轻教员作为研究人员的共同导师，从而改善学习环境，并为未来的导师提供指导环境。该计划将通过在哈佛医学院和公共卫生学院进行基础科学和实验技术的正式课程学习的机会，通过与NIH资助的消化疾病中心(HMS和MGH)的核心实验室和研究人员的互动，以及通过参加每个机构提供的临床和研究会议来丰富该计划。培训计划执行委员会(Soybel、Hodin、Hasselgren)负责监督受训人员的选择、教师的指定、正式课程的规定以及受训人员参与教授伦理学和负责任的研究行为的计划。受训人员是通过向外科住院医师或经认可的美国外科住院医师培训计划的研究员开放的程序挑选出来的。通过卫生管理处的多样性办公室和每个参与机构，协调积极主动地向属于人数不足的少数群体的个人寻求申请。表演网站========================================Section End===========================================

EXCEED THE SPACE PROVIDED. This Program provides research training for young surgeons who plan careers for patient care and investigation in surgical problems of the alimentary tract. Its primary purpose is to prepare these individuals to become independently funded investigators. The program provides intensive, coordinated research training in fundamental aspects of molecular and cell biology, biochemistry and biophysics, organ physiology and pathophysiology, and immunology, as they apply to diseases of the alimentary tract, hepatobiliary system and pancreas. First funded in 1997 as a collaboration between the Departments of Surgery at the Brigham and Women's Hospital and the former Beth Israel Hospital, this program is now expanded to include NIH-funded surgical research laboratories at all major adult teaching hospital affiliates of Harvard Medical School. Current areas of investigation by core preceptor group include: 1) gastro-intestinal mucosal secretion and barrier function (Soybel, Hofer, Hagen); 2) energetics and metabolic derangements of liver in sepsis and shock (Fischer, Hasselgren); 3) gut differentiation and growth responses to starvation or massive resection (Hodin, Ashley, Zinner); 4) cell biology and pathophysiology of acute and chronic pancreatitis (Warshaw); 5) molecular basis of pancreatic cancer growth and metastasis (Callery); 6) tissue engineering as applied to reconstruction and rehabilitation of the alimentary tract (Vacanti, Whang); and 7) evaluation of outcomes and introduction of new technologies in operations on the Digestive System (Zinner, Warshaw, Daley). In addition, a number of young faculty have been recruited to the different Departments of Surgery at HMS, with intention of their development as surgeon-investigators in the field of GI and HPB Surgery. We propose to include these young faculty, under clearly specified circumstances, as co- mentors of our research fellows, thereby enhancing the environment for learning and providing an environment of mentoring for future mentors. The program will be enriched by opportunties for formal coursework in basic sciences and experimental techniques at Harvard's Medical School and School of Public Health, by interactions with core labs and investigators of the NIH-funded Digestive Diseases Centers (HMS-based and MGH-based), and by participation in clinical and research conferences offered at each institution. The training Program Executive Committee (Soybel, Hodin, Hasselgren) oversees selection of trainees, designation of precptors, prescription of formal coursework, and participation of trainees in programs teaching ethics and responsible conduct in research. Trainees are selected through a process open to surgical residents or fellows in accredited U.S. Surgical Residency Training Programs. A pro-active process for seeking applications from individuals belonging to under-represented minority groups is coordinated through the Offices for Diversity at HMS and each of the participating institutions. PERFORMANCE SITE ========================================Section End===========================================