UT Gastroenterology/Hepatology Research Training Program

BB主要研究者/项目负责人（最后，第一，中间）：DIETSCHY。约翰·莫里斯描述说明申请的广泛、长期目标和具体目标，并提及项目的健康相关性。简明扼要地描述研究的设计和方法，以达到他的帕尔斯。避免总结过去的成就和第一人称。本说明旨在作为简明准确的说明，^^即与申请分开时的拟议工作^^fc如果申请获得资助，本说明将成为公开信息。因此，不包括专有/机密信息。请勿超过所提供的空间。在UT胃肠病学/肝病研究培训计划的培训发生在消化和肝病科的实验室和在几个基础科学部门的实验室在得克萨斯州西南医学中心和达拉斯退伍军人事务医学中心校园的大学。在约翰·M博士的指导下，Dietschy，Stuart J. Spechler and Doggel. Thiele，申请人经过仔细筛选和面试。每个成功的申请人将在高级研究学院的一名或多名成员的直接监督下进行为期两到四年的重大研究项目。此外，每个学员将与其他高级研究学院和各基础科学部门的成员进行密切互动。这些教师实验室正在进行的项目非常多样化，涉及细胞和分子生物学的各种技术。代表性项目包括详细研究胆汁酸生物合成的替代生化途径的性质，孤儿核受体在控制胆汁酸合成和固醇转运中的作用，丙型肝炎新疗法的分析，细胞毒性淋巴细胞在肝炎和炎症性肠病等疾病中的作用，以及新描述的胆固醇24羟化酶和ABCA 1胆汁胆固醇分泌蛋白质。最初，所有学员都参加伦理生物学研究的正式讲座，并在全年参加定期研究会议和临床会议。此外，还有一个为期两年的讲座周期，专门介绍胃肠道器官的生理学，分子生物学和细胞生物学。在这两到四年的密集研究工作过程中，学员将学习利用分子和细胞生物学常见的各种基本实验室程序。如果受训者从事临床研究，他/她将参加为期一年的人体研究各方面的正式课程。所有受训人员的进展情况定期监测，在这一紧张的研究期结束时，每个受训人员也将有机会完成他/她的临床培训。在医学研究中使用动物和人类伦理调查的特殊问题方面有正式的课程。有一个积极的方案，招募代表性不足的少数民族。 性能现场=

BB Principal Investigator/Program Director (Last, first, middle): DIETSCHY. John Maurice DESCRIPTION. State the application's broad, long-term objectives and specific aims,making reference to the health relatednessofthe project. Describe concisely the research design and methods for achieving thaj^pals.Avoid summaries of past accomplishments and the^e of the first person. This description is meant to serve as a succinct and accurate description^^ie proposed work when separated from the applic^^fc If the application is funded, this description, as is, will become public information. Therefore, do not include proprietary/confidential information. DO NOT^CCEED THE SPACE PROVIDED. Training in the UT Gastroenterology/Hepatology Research Training Program takes place in the laboratories of the Division of Digestive and Liver Diseases and in the laboratories of several basic science departments at The University of Texas Southwestern Medical Center and the Dallas Veteran's Affairs Medical Center campuses. Under the direction of Drs. John M. Dietschy, Stuart J. Spechler and Dwain L. Thiele, applicants are carefully screened and interviewed. Each successful applicant will undertake a major research project for two to four years under the direct supervision of one or more members of the Senior Research Faculty. In addition, each trainee will have close interactions with other Senior Research Faculty and with members of various basic science departments. The projects that are ongoing in the laboratories of these faculty members are very diverse and involve a wide variety of techniques in cellular and molecular biology. Representative projects include detailed studies into the nature of alternative biochemical pathways for the biosynthesis of bile acids, the role of orphan nuclear receptors in the control of bile acid synthesis and sterol transport, an analysis of new treatments for hepatitis C, the role of cytotoxic lymphocytes in diseases such as hepatitis and inflammatory bowel disease and the role of newly described cholesterol 24 hydroxylase and the ABCA1 protein in biliary cholesterol secretion. Initially all trainees attend formal lectures in the performance of ethical biological research and,throughout the year, participate in regular research conferences and clinical conferences in the division. In addition, there is a two year cycle of lectures devoted to the physiology, molecular biology and cell biology of the organs of the gastrointestinal tract. Throughout this two to four year course of intense research work, the trainees will learn to utilize a variety of basic laboratory procedures common to molecular and cell biology. If the trainee is engaged in clinical investigation, he/she will participate in a year long formal course in various aspects of human research. The progress of all trainees is monitored on a regular basis and, at the end of this intense period of research, each trainee will also have the opportunity of completing his/her clinical training. There are formal courses in the use of animals in medical research and in the special problems of ethical human investigation. There is an active program for recruiting underrepresented minorities. PERFORMANCE SITE ========================================Section End===========================================